The Effects of Marijuana on Orientation and Motor Coordination and Brain Metabolism in Regular Smokers of Marijuana

Not Applicable

Completed

• Conditions: Marijuana Dependence
• Interventions: Drug: Tetra Hydro Cannabinol (THC)

• Registration Number: NCT00270803
• Lead Sponsor: Tel-Aviv Sourasky Medical Center

Brief Summary

This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana. Subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana.On both occasions they performed on a virtual reality maze task. They were afterwards scanned in Positron Emission Tomography (PET) with Fluoro-deoxy-glucose (FDG).

Detailed Description

This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana. Subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana. On both occasions they performed on a virtual reality maze task. They were afterwards scanned in Positron Emission Tomography (PET) with Fluoro-deoxy-glucose (FDG). 12 subjects were tested so far on both conditions.

Study Timeline

• Study Start: 2004-07
• Status Verified: 2005-12
• Primary Completion: 2005-12
• Study Completion: 2005-12
• Study First Submitted: 2005-12-25
• Study First Submitted QC: 2005-12-25
• Study First Posted: 2005-12-28
• Last Update Submitted: 2008-05-06
• Last Update Posted: 2008-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Marijuana dependence
• Age 20-65
• Male and female

Exclusion Criteria

• Pregnant women
• Dependence on other substances
• Psychiatric diagnosis apart from marijuana dependence
• Neurological disorder
• Young persons

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
A	Tetra Hydro Cannabinol (THC)	Low nicotine cigarettes without THC

Primary Outcome Measures

Name	Time	Method
Brain metabolic activity (FDG)	30-40 minutes

Secondary Outcome Measures

Name	Time	Method
Reaction time (RTs) and errors in performance	40 minutes
Subjective ratings on visual analog scale	10 minutes

Trial Locations

Locations (1)

Department of Nuclear Medicine; 🇮🇱 Tel Aviv, Israel