The Effects of Marijuana on Orientation and Motor Coordination and Brain Metabolism in Regular Smokers of Marijuana.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Brain metabolic activity (FDG)
研究概览
简要总结
This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana. Subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana.On both occasions they performed on a virtual reality maze task. They were afterwards scanned in Positron Emission Tomography (PET) with Fluoro-deoxy-glucose (FDG).
详细描述
This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana. Subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana. On both occasions they performed on a virtual reality maze task. They were afterwards scanned in Positron Emission Tomography (PET) with Fluoro-deoxy-glucose (FDG). 12 subjects were tested so far on both conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Marijuana dependence
- •Age 20-65
- •Male and female
排除标准
- •Pregnant women
- •Dependence on other substances
- •Psychiatric diagnosis apart from marijuana dependence
- •Neurological disorder
- •Young persons
研究组 & 干预措施
A
Low nicotine cigarettes without THC
干预措施: Tetra Hydro Cannabinol (THC) (Drug)
结局指标
主要结局
Brain metabolic activity (FDG)
时间窗: 30-40 minutes
次要结局
- Reaction time (RTs) and errors in performance(40 minutes)
- Subjective ratings on visual analog scale(10 minutes)