NCT03348631进行中（未招募）2 期
A Phase II Study of Tazemetostat (EPZ-6438) in Recurrent or Persistent Endometrioid or Clear Cell Carcinoma of the Ovary, and Recurrent or Persistent Endometrioid Endometrial Adenocarcinoma
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 进行中（未招募）
- 入组人数
- 62
- 试验地点
- 1,161
- 主要终点
- Tumor Response
研究概览
简要总结
This phase II trial studies how well tazemetostat works in treating patients with ovarian or endometrial cancer that has come back (recurrent). Chemotherapy drugs, such as tazemetostat, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
详细描述
PRIMARY OBJECTIVES:
I. To assess the clinical activity (overall response rate) of tazemetostat in patients with recurrent or persistent endometrioid or clear cell ovarian carcinoma, and patients with recurrent or persistent endometrioid endometrial adenocarcinoma.
II. To assess the clinical activity (response frequency) of tazemetostat in patients with recurrent or persistent clear cell ovarian carcinoma with an ARID1A mutation.
SECONDARY OBJECTIVES:
I. To examine the nature and degree of toxicity in patients with this regimen. II. To examine the progression free survival and overall survival for this patient population receiving tazemetostat.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pathologically (histologically or cytologically) proven diagnosis of recurrent or persistent ovarian endometrioid or clear cell carcinoma, OR recurrent or persistent endometrioid endometrial adenocarcinoma; patients with recurrent endometrial cancer must have mismatch repair (MMR) immunohistochemistry completed; if they are found to be mismatch repair deficient, they should be offered treatment with immune checkpoint inhibition before consideration for treatment on trial; primary ovarian tumors must be at least 50% endometrioid or clear cell morphology, or have histologically documented recurrence with at least 50% endometrioid or clear cell morphology; institutional pathology reports must be provided indicating at least 50% endometrioid or clear cell morphology for ovarian tumors (primary or recurrent lesions)
- •Only patients with recurrent or persistent ovarian clear cell carcinoma (OCCC) with ARID1A pathologic variant or likely pathologic variant mutations per next generation sequencing (NGS) are eligible for entry (20-OCT-2021)
- •Institutional pathology reports must be provided indicating at least 50% clear cell morphology for ovarian tumors (primary or recurrent lesions) and NGS report must be available for step 1 registration (20-OCT-2021) (09-DEC-2021)
- •All other eligibility criteria and ineligibility criteria must be met for step 2 registration (20-OCT-2021) (09-DEC-2021)
- •All patients must have measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) version (v) 1.1; measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded); each lesion must be >= 10 mm when measured by computed tomography (CT), magnetic resonance imaging (MRI) or caliper measurement by clinical exam; or >= 20 mm when measured by chest x-ray; lymph nodes must be >= 15 mm in short axis when measured by CT or MRI
- •Patients must have had at least one, but no more than 3, prior cytotoxic regimens for management of primary disease; unlimited prior hormonal therapy, targeted therapy (including immunotherapy) or antiangiogenic therapy will be permitted
- •Patients must have completed prior therapy:
- •Chemotherapy: cytotoxic
- •At least 28 days since last dose of chemotherapy prior to step 2 registration.
- •Chemotherapy: nitrosoureas
- •At least 6 weeks since last dose of chemotherapy prior to step 2 registration.
- •Chemotherapy: non-cytotoxic (e.g. small molecule inhibitor)
- •At least 28 days since last dose of chemotherapy prior to step 2 registration.
- •Monoclonal antibody(ies)
- •At least 28 days since last dose of monoclonal antibody prior to step 2 registration.
- •Immunotherapy
- •At least 28 days since last dose of immunotherapy prior to step 2 registration.
- •Radiotherapy (RT)
- •At least 14 days from last local site RT prior to step 2 registration.
- •At least 21 days from stereotactic radiosurgery prior to step 2 registration.
- •At least 12 weeks from craniospinal, >= 50% radiation of pelvis or total body irradiation prior to step 2 registration.
- •Patients with central nervous system (CNS) disease should demonstrate evidence of stabilization after the 28-day time point after definitive treatment.
- •Full recovery of radiation related side effects prior to step 2 registration.
- •All subjects must have evidence of measurable disease outside of the radiation field at the time of step 2 registration
- •Appropriate stage for study entry based on the following diagnostic workup:
- •History/physical examination within 14 days prior to step 2 registration
- •Imaging of the chest, abdomen and pelvis within 28 days prior to step 2 registration
- •Age >= 18
- •Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2 within 14 days prior to step 2 registration
- •Platelets >= 100,000/mcl (within 14 days prior to step 2 registration)
- •Absolute neutrophil count (ANC) >= 1,500/mcl (within 14 days prior to step 2 registration)
- •Hemoglobin >= 8 g/dL (within 14 days prior to step 2 registration)
- •Differential with no clinically significant morphologic abnormalities on complete blood count (CBC) testing; manual differential is encouraged, if clinically indicated, and in cases where an automated differential is abnormal (within 14 days prior to step 2 registration)
- •Creatinine =< 1.5 x institutional/laboratory upper limit of normal (ULN) (within 14 days prior to step 2 registration)
- •Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (within 14 days prior to step 2 registration)
- •Total serum bilirubin level =< 1.5 x ULN; direct bilirubin =< ULN for subjects with total bilirubin > 1.5 x ULN (patients with isolated indirect bilirubin elevations and a history of Gilbert's syndrome are eligible) (within 14 days prior to step 2 registration)
- •Patients must be able to swallow and retain oral medications and not have gastrointestinal illnesses that would preclude absorption of tazemetostat as judged by the treating physician (20-OCT-2021)
- •Women of childbearing potential must be willing and able to use adequate contraception (hormonal and barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 6 months after the last dose of study agent; should a woman become pregnant or suspect she is pregnant while she is participating in this study, she should inform her treating physician immediately; theoretically, CYP3A induction with tazemetostat use may result in the loss of efficacy in hormonal contraceptives, thus a barrier method of contraception must be used in addition to hormonal contraceptives due to the potential drug-drug interaction with tazemetostat (20-OCT-2021)
- •The patient or a legally authorized representative must provide study-specific informed consent and authorization permitting release of personal health information prior to study entry
- •Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial (08/13/2019)
排除标准
- •Prior treatment with an investigational EZH2 inhibitor
- •A prior history of myeloid malignancies, including myelodysplastic syndrome (MDS)
- •Abnormalities known to be associated with MDS (e.g. del 5q, chr 7 abn) and myeloproliferative neoplasms (MPN) (e.g. JAK2 V617F) observed in cytogenetic testing and deoxyribonucleic acid (DNA) sequencing
- •A prior history of T-cell lymphoblastic lymphoma (T-LBL)/T-cell acute lymphoblastic leukemia (T-ALL)
- •Patients who have had therapeutic paracentesis or thoracentesis within 8 weeks prior to step 2 registration (20-OCT-2021)
- •Patients with clinical or radiographic evidence of bowel obstruction (20-OCT-2021)
- •Severe, active co-morbidity per the treating investigator's discretion
- •Pregnant or lactating patients
- •Known human immunodeficiency virus (HIV) positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with tazemetostat; in addition, treatments involved in this protocol may be immunosuppressive, increasing the risk of lethal infections in this patient population
- •Treatment with strong and moderate inhibitors or inducers of CYP3A within 14 days of step 2 registration and during the study treatment (20-OCT-2021)
研究组 & 干预措施
Treatment (tazemetostat)
Experimental
Patients receive tazemetostat PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT scans and MRI on study.
干预措施: Magnetic Resonance Imaging (Procedure)
Treatment (tazemetostat)
Experimental
Patients receive tazemetostat PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT scans and MRI on study.
干预措施: Tazemetostat (Drug)
Treatment (tazemetostat)
Experimental
Patients receive tazemetostat PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT scans and MRI on study.
干预措施: Computed Tomography (Procedure)
结局指标
主要结局
Tumor Response
时间窗: Up to 6 months
Will be defined by Response Evaluation Criteria in Solid Tumors (RECIST) version (v) 1.1. The statistic reported is the response rate (i.e. (total responses / total at risk) \* 100).
次要结局
- Tumor Response in Patients With ARID1A Mutations Using Tumor Response (Removed as of Version Date 20-OCT-2021)(Up to 6 months)
- 6-month Progression Free Survival (Clinical Benefit Rate)(Up to 6 months)
- Number of Patients With a Grade 3 (or Higher) Adverse Events(Adverse events were collected for a maximum of 23.5 months (interquartile range: 1.4 months, 3.9 months).)
- Progression-free Survival(Progression-free survival times were collected for a maximum of 30.0 months (interquartile range: 1.8 months, 5.5 months).)
- Overall Survival(Overall survival times were collected for a maximum of 51.6 months (interquartile range: 4.3 months, 19.0 months).)
研究者
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