Exercise to Slow Cardiovascular Ageing Progression

Recruiting

• Conditions: Cardiac Ageing; Exercise; Cardiovascular

• Registration Number: NCT05775484
• Lead Sponsor: National Heart Centre Singapore

Brief Summary

In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.

Detailed Description

Participants from each stratum will be randomized to receive either an exercise program intervention or no exercise. At the start and end of study, participants will undergo cardiovascular imaging and metabolic profiling. Investigators will determine if exercise can reverse high-risk metabolic profiles and improve cardiovascular structure and function.

Without clear mechanisms to explain cardiovascular ageing nor interventions known to retard cardiovascular ageing, our approach will provide much needed translational evidence to incorporate targeted interventions aimed at reducing cardiovascular disease risk in older populations.

Study Timeline

• Study First Submitted: 2023-02-10
• Study First Submitted QC: 2023-03-07
• Study First Posted: 2023-03-20
• Status Verified: 2023-05
• Study Start: 2023-05-01
• Last Update Submitted: 2023-05-10
• Last Update Posted: 2023-05-11
• Primary Completion: 2026-12-31
• Study Completion: 2051-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 450

Inclusion Criteria

• Age >=21 years old
• Outdoor ambulant

Exclusion Criteria

• Wheelchair or bed-bound
• Dementia
• Residing in sheltered or nursing home
• Cancer
• Participation in ongoing clinical trials that involve interventional drugs or devices
• Aneurysms
• Acute infections (in the last six months)
• Uncontrolled thyrotoxicosis
• Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise
• Uncontrolled asthma or chronic lung disease
• Restrictive lung disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Metabolite profiles	12 Months	To measure changes in serum metabolite levels among participants pre and post exercise intervention.
Cardiovascular structure and function	12 Months	To measure changes in CV structure and function (diastolic function, arterial stiffness) among participants.

Trial Locations

Locations (1)

National Heart Centre Singapore; 🇸🇬 Singapore, Singapore