Exercise to Slow Cardiovascular Ageing Progression
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 450
- 试验地点
- 1
- 主要终点
- Cardiovascular structure and function
研究概览
简要总结
In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.
详细描述
Participants from each stratum will be randomized to receive either an exercise program intervention or no exercise. At the start and end of study, participants will undergo cardiovascular imaging and metabolic profiling. Investigators will determine if exercise can reverse high-risk metabolic profiles and improve cardiovascular structure and function.
Without clear mechanisms to explain cardiovascular ageing nor interventions known to retard cardiovascular ageing, our approach will provide much needed translational evidence to incorporate targeted interventions aimed at reducing cardiovascular disease risk in older populations.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age >=21 years old
- •Outdoor ambulant
排除标准
- •Wheelchair or bed-bound
- •Residing in sheltered or nursing home
- •Participation in ongoing clinical trials that involve interventional drugs or devices
- •Aneurysms
- •Acute infections (in the last six months)
- •Uncontrolled thyrotoxicosis
- •Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise
- •Uncontrolled asthma or chronic lung disease
- •Restrictive lung disease
结局指标
主要结局
Cardiovascular structure and function
时间窗: 12 Months
To measure changes in CV structure and function (diastolic function, arterial stiffness) among participants.
Metabolite profiles
时间窗: 12 Months
To measure changes in serum metabolite levels among participants pre and post exercise intervention.
次要结局
未报告次要终点