Acute Effects of Natural and Interesterified Fats-formulated Margarine on Lipemic and Insulinemic Response
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Change in serum triglycerides level of subjects as a measure of postprandial triglycerides response
研究概览
简要总结
Interesterified (IE) fat blends will respond differently in terms of postprandial lipemia and insulinemic responses compare to a trans free palm margarine (TFPM).
详细描述
The objective of this study was to investigate whether IE-fat blends behave differently on postprandial serum lipid, insulin, C-peptide and glucose concentration compare to TFPM. A randomised, double-blind crossover (3 × 3 arms) orthogonal Latin-square design was used and conducted on 10 males and 10 females adults. During postprandial challenge day, each subject received an a test muffin incorporated with test margarine. Blood samples were collected at half-hourly intervals until 4 hr by using cannulation technique.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Body Mass Index (BMI) between 18.5 and 24.9
- •<130mmHg for systolic pressure and <80 mmHg for diastolic pressure
- •Blood glucose level in the range of 3.9 to 5.5 mmol/L
- •Total cholesterol less than 5.17 mmol/L
- •No use of tobacco and no consumption of alcohol.
排除标准
- •Suffer from chronic disease
- •Metabolic syndrome
- •Consuming any medical prescriptions
- •People with blood clotting problem
- •Women who are pregnant
- •Hypertensive person
结局指标
主要结局
Change in serum triglycerides level of subjects as a measure of postprandial triglycerides response
时间窗: Baseline, 4 hours
次要结局
- Change in the level of plasma insulin, c-peptide and serum glucose as a measure of postprandial insulinemic response(Baseline, 4 hours)