Mood Disorders in Elderly and ECT (Electroconvulsive therapy): Electroconvulsive therapy can induce brain derived neurotrophic factor in serum and increase cortisol levels to enhance neurorestorement of hippocampal volume and function.

Completed

• Conditions: psychotic depression; severe depression; 10027946

• Registration Number: NL-OMON47034
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

severe depression conform DSM IV criteria egible for electroconvulsive therapy, inpatient, 60 years and older

Exclusion Criteria

dementia, younger than 60 years
severe neurological disorder
incapacity to give informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>clinical parameters predict safety and effect of ECT<br /><br>MRI findings predict safety and effect of ECT<br /><br>lack of cortisol response predicts response to ECT<br /><br>BDNF increases after ECT and there is neurorestorement of hippocampal volume<br /><br>genetic profile predicts clinical parameters and effect of ECT</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>there are no secundary study parameters</p><br>