Relationship Between Cardiovascular Disease in Asthma and Eosinophil Subtypes and Biomarkers of Bronchial Remodeling.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 主要终点
- Clinical characteristics of patients with asthma
研究概览
简要总结
To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease.
详细描述
Recent studies have shown that asthma could be a risk factor for cardiovascular disease, especially in the female and late-onset subgroups. The two entities share several risk factors, such as chronic inflammation and bronchial remodeling. Eosinophilia, characteristic of asthma, has also been described as a predictor of cardiovascular mortality.
The aim of this study is to determine the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Previous diagnosis of asthma
- •Signed informed consent
排除标准
- •Age under 18 years old
- •Age over 99 years old
- •Pneumological diseases other than asthma
- •Active oncological diseases or with end of treatment <5 years
- •Autoimmune or systemic inflammatory diseases
结局指标
主要结局
Clinical characteristics of patients with asthma
时间窗: 1 year
Spirometry with bronchodilator testing
Associated cardiovascular disease type
时间窗: 1 year
Cardiac infarction, stroke or peripheral artery disease
次要结局
- Eosinophil subtypes(1 year)
- Bronchial remodeling(1 year)
- Biomarkers of chronic inflammation(1 year)