PSMA changes in the peripheral nociceptive system in 5 pain phenotypes

• Conditions: R52.9; Pain, unspecified

• Registration Number: DRKS00014335
• Lead Sponsor: niversitätsklinikum Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-04-16
• Study Completion: 2020-08-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

Diabetes mellitus-induced neuropathic pain
1. capable of giving consent
2. age = 50 years
3. diabetes mellitus
4. neuropathic pain

Cancer chemotherapy-induced neuropathy pain
1. capable of giving consent
2. age = 50 years
3. neuropathic pain
4. group after chemotherapy

Nerve injury-induced neuropathic pain
1. capable of giving consent
2. age = 50 years
3. neuropathic pain after nerve injury

Reactive/inflammation-induced visceral pain
1. capable of giving consent
2. age = 50 years
3. visceral pain of reactive or inflammatory origin

inflammatory arthrosis
1. capable of giving consent
2. age = years
3. inflammatory arthrosis
4. pain as a result of inflammatory arthrosis

Exclusion Criteria

Diabetes mellitus-induced neuropathic pain
1. any radiation exposure for scientific purposes within the last 10 years.

Cancer chemotherapy-induced neuropathy pain
1. any radiation exposure for scientific purposes within the last 10 years.

Nerve injury-induced neuropathic pain
1. any radiation exposure for scientific purposes within the last 10 years.

Reactive/inflammation-induced visceral pain
1. any radiation exposure for scientific purposes within the last 10 years.

inflammatory arthrosis
1. any radiation exposure for scientific purposes within the last 10 years.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Signal intensity and segmental extension of the PSMA tracer over a period of 1-3 hours after tracer injection in relation to reference regions such as musculature

Secondary Outcome Measures

Name	Time	Method
- Signal intensity of the PSMA tracer in reference regions (e.g. salivary glands, blood pool, liver, spleen and muscles)<br>- Time course of PSMA PET signal intensity in reference regions (e.g. salivary glands, blood pool, liver, spleen and muscles)<br>- Comparison of PSMA PET signal intensity in different pain conditions