The Relation Between Abdominal Obesity, Type 2 Diabetes Mellitus and Knee Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 126
- 试验地点
- 1
- 主要终点
- Femoral cartilage thickness
研究概览
简要总结
Background:Knee osteoarthritis is more common in patients with type-2 diabetes mellitus, however it is not known whether this effect is caused by diabetes itself or concominant abdominal obesity.
Objectives:The aim of this study is to determine whether type-2 diabetes itself, independent of abdominal obesity, is a risk factor for femoral cartilage, knee osteoarthritis and poor quality of life.
Design:A cross-sectional design. Settings:Training and research hospital in Turkey. Patients and Methods:Female patients was enrolled in this study and divided into two groups: according to presence or absence of diabetes. Later, both the patients with and without abdominal obesity was divided into two groups according the presence of diabetes.
Main Outcome measures:Clinical parameters were visual analog-scale, gait speed and short form-36. Knee radiographs were evaluated according to Kellgren Lawrance-Scale. And ultrasonography parameters were the measurements of distal femoral cartilage thickness.
Sample size:126
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •being female
- •aged between 40 and 70.
排除标准
- •Patients with any concomitant chronic disease
- •rheumatoid arthritis
- •cardiac diseases (except type 2 diabetes mellitus and hypertension)
- •knee surgery
- •bone mass or cancer
- •inflammatory arthritis
- •impaired cognitive status
- •immobilized patients
- •type 1 diabetes mellitus
结局指标
主要结局
Femoral cartilage thickness
时间窗: baseline
Measured by ultrasonography (higher value:thick cartilage, lower value:thin cartilage)
次要结局
- visual analog scale(baseline)
- radiographic knee osteoarthritis(baseline)
研究者
Fulya Bakılan
principal investigator
Eskisehir City Hospital