CTRI/2019/09/021205CompletedUnknown
Evaluation of topical effect of Probiotic formulation on Streptococcus mutans count in plaque in 7-12 year old children
STES Sinhgad dental college and hospital1 site in 1 country10 target enrollmentStarted: September 16, 2019Last updated:
Conditions
Trial Snapshot
- Phase
- Unknown
- Status
- Completed
- Sponsor
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Reduction in plaque Streptococcus mutans counts of children
Study Overview
Brief Summary
Probiotics compete with tooth decay causing bacteria for carbohydrate resulting in substrate depletion, hence short term topical application of probiotics on teeth can replace cariogenic bacteria, Streptococcus mutans, resulting in reduced caries activity.
In this RCT on 10 children of 7-12 yrs age, topical probiotic application for 6 days showed >90% reduction in S.mutans count of oral plaque. Hence probiotic can be used as topical agent for caries prevention in children.
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant and Outcome Assessor Blinded
Eligibility Criteria
- Ages
- 7.00 Year(s) to 12.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Healthy Children with dmft/DMFT score 2-5.
Exclusion Criteria
- •Free from systemic disease.
Outcomes
Primary Outcomes
Reduction in plaque Streptococcus mutans counts of children
Time Frame: post 6 days
Secondary Outcomes
- Reduction in Dental caries(2 months)
Investigators
Study Sites (1)
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