Immunological profile of women with HPV in comparison to women without HPV
- Conditions
- Health Condition 1: C530- Malignant neoplasm of endocervix
- Registration Number
- CTRI/2021/03/032288
- Lead Sponsor
- Manipal Academy of higher education
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion criteria for the phase-1 study:
All physically and mentally competent sexually exposed married women with cervico-vaginal intraepithelial neoplasias (CIN) or histologically confirmed cervical squamous cell cancers and retro-positive women with or without cytological abnormalities and women attending routine check-ups will be enrolled.
Inclusion criteria for the phase-2 study:
Age group between 18 to 45 years who can complete the questionnaires in English or Kannada.
Exclusion criteria for the phase-1 study:
Pregnant women, Women below 30 years, and women above 65 years of age, except those with diagnosed cancer cervix, where irrespective of age, women will be included, Women with auto-immune diseases, Women who previously received immunosuppressive treatment, radiotherapy, or chemotherapy, Women with a history of taking anti-inflammatory drugs within two weeks before sampling, Women who are actively taking oral contraceptives.
Exclusion criteria for the phase-2 study:
Pregnant women, women with history of hysterectomy
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Our study will give information about immunological profile of genital HPV infected <br/ ><br>immunocompetent women and women having concurrent HIV infection <br/ ><br>Timepoint: 3 years <br/ ><br>
- Secondary Outcome Measures
Name Time Method This study is expected to provide a sound rationale for decision making with respect to vaccination.Timepoint: 2