Effects of Cold Atmospheric Plasma (CAP) on Peritoneal Tumor Tissue

Not Applicable

Recruiting

• Conditions: Cold Atmospheric Plasma (CAP); J-Plasma; Peritoneal Tumor

• Registration Number: NCT06796634
• Lead Sponsor: University Hospital, Ghent

Brief Summary

There are to date no studies available that have examined the effects of CAP on tumor tissue in patients. The aim of this study is to investigate these effects in patients undergoing surgery for peritoneal metastases. Tumor nodules will be treated with different durations and intensities of CAP before being surgically removed. The resected nodules will be analyzed for tumor vitality.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-08-21
• Status Verified: 2025-01
• Study First Submitted: 2025-01-22
• Study First Submitted QC: 2025-01-27
• Last Update Submitted: 2025-01-27
• Study First Posted: 2025-01-28
• Last Update Posted: 2025-01-28
• Primary Completion: 2025-04-01
• Study Completion: 2025-04-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
- Histology:	1 year	Following resection, FFPE sections will be assessed morphologically, particularly for the extent of tumor necrosis using haematoxylin and eosin staining. IHC staining will be performed to investigate mechanisms of autophagia (p62 and LC3B), apoptosis (cleaved caspase 3) and proliferation (ki67).; * Extent of tumor necrosis: morphological assessment; * Proliferation: Ki67 via MIB1; * Autophagia: p62 or LC3B; * Apoptosis: Caspase 3 antibodies

Trial Locations

Locations (1)

UZ Ghent; 🇧🇪 Ghent, East-Flanders, Belgium