Evaluation of the Role of Poisoning Severity Score, Serum Procalcitonin and C-reactive Protein in Acute Hydrocarbon Intoxicated Cases Admitted to the Poison Control Center Ain Shams University Hospitals

Not yet recruiting

• Conditions: Acute Hydrocarbon Toxicity
• Interventions: Diagnostic Test: serum procalcitonin; Diagnostic Test: C-reactive protein

• Registration Number: NCT06151301
• Lead Sponsor: Sohag University

Brief Summary

Hydrocarbons are a primary energy source in modern society. They are present in many common household and occupational products, including motor fuels, paint thinners, cleaning agents, lotions, and industrial solvents. Unfortunately, these products are also used as agents of abuse and typically inhaled .

They are derived mainly from petroleum (kerosene, gas, naphtha) or wood (turpentine, pine oil). They can be found in liquid, gas, or solid form depending on their properties. All hydrocarbons can be toxic, but aromatic (ring-shaped) and halogenated hydrocarbons typically have more severe toxicity .

Toxicity occurs in various ways including through inhalation, ingestion, aspiration, and dermal exposure. Frequently, these exposures occur during attempted recreational use of the substances and sometimes for self-injurious behavior

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-11
• Study First Submitted: 2023-11-21
• Study First Submitted QC: 2023-11-21
• Last Update Submitted: 2023-11-21
• Study First Posted: 2023-11-30
• Last Update Posted: 2023-11-30
• Study Start: 2023-12-01
• Primary Completion: 2024-12-01
• Study Completion: 2024-12-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients of both sexes admitted to the Poison control center, Ain Shams university hospitals with acute hydrocarbon toxicity during the duration from December 2023 till December 2024 with a maximum number of 60 cases within 24 hours of intoxication.

Exclusion Criteria

Patients with these criteria will be excluded:

• Cases > 24 hours of intoxication.
• Cases with occupational exposure to hydrocarbons.
• Pregnant females.
• Any cases received any treatment before arrival to the PCC.
• Cases suffering from cardiac, respiratory, renal, hepatic or haematological disorders.
• Cases presenting with fever.
• Cases with other causes that can increase levels of CRP & pro-calcitonin as bacterial infection, recent major trauma, major burn ,septic shock and medullary thyroid cancer.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
control group	C-reactive protein	20 subjects of apparently healthy persons for estimating the standard levels of the tested biomarkers.
case group	serum procalcitonin	60 patients divided into mild, moderate and severe toxicity according to the poisoning severity score.
control group	serum procalcitonin	20 subjects of apparently healthy persons for estimating the standard levels of the tested biomarkers.
case group	C-reactive protein	60 patients divided into mild, moderate and severe toxicity according to the poisoning severity score.

Primary Outcome Measures

Name	Time	Method
Serum procalcitonin level	1 year	measuring the level of serum procalcitonin (reference range 0-0.05µg/L)

Trial Locations

Locations (1)

Ain Shams university Hospital; 🇪🇬 Cairo, Egypt