NCT03737682已完成不适用
Hemostasis Achievement Reflecting Inflammatory Status of the Pulp Based on Cytokine Levels: A Cohort Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- Measuring interleukin 2 (IL-2)
研究概览
简要总结
Assessment of pulp inflammation by hemostasis achievement after pulp exposure
详细描述
The possibility has been raised of diagnosing pulpal pathological status using the cytokines that are released during the inflammation process in healthy as well as infected tooth pulp. Cytokines are small polypeptides secreted by leucocytes and other inflammatory cells and are known to play important roles in the intensity and duration of the immune response
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 5 Years 至 7 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •healthy children
- •patients had not used any inflammatory medications
- •primary molar teeth of these children were included based on the following clinical and radiographic criteria:
- •no clinical symptoms or evidence of pulp degeneration (pain on percussion, history of swelling or sinus tract
- •no spontaneous pain
- •no radiographic signs of internal or external resorption, widened periodontal ligament space, or furcal/periapical radiolucency
- •physiological root resorption of no more than one third the root length
- •a deep caries lesion with a likelihood of pulp exposure during caries removal
排除标准
- •patients used any anti-inflammatory medication
结局指标
主要结局
Measuring interleukin 2 (IL-2)
时间窗: After 5 minutes
to measure cytokines levels after coronal pulpal removal
次要结局
- Measuring interleukin 6 (IL-6) and interleukin 8 (IL-8)(After 5 minutes)
- Postoperative pain, Bifurcation/periapical radiolucency and Internal/external root resorption Or other pathological changes(3,6,9,12 months)
研究者
Samah Mohsin
principal investigator
Cairo University
研究点 (1)
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