NCT01048216Unknown不适用
Partial Liver Radiotherapy for Patients With Unresectable Colorectal Liver Metastases
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- To evaluate feasibility of conformal radiation therapy in patients with metastatic colorectal liver cancer and determine its safety
研究概览
简要总结
This study is designed to treat tumors in the liver that cannot be removed surgically and chemotherapy cannot control these tumors, using radiation therapy and a more precise delivery than has been used before.
详细描述
The purpose of this study is to evaluate safety and feasibility of conformal radiation therapy in patients with metastatic colorectal liver cancer. This study would also evaluate local control rate within irradiated area and to assess failure patterns and survival of patients treated with conformal liver radiation.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •liver metastases unequivocally seen on contrast enhanced CT and/or MRI from colon or rectal cancer, previously confirmed pathologically as adenocarcinoma
- •either 1) the tumor must be unresectable, 2) the patient must be medically inoperable, or 3) extra-hepatic metastases are present (making hepatic surgery an inappropriate treatment option)
- •good performance status (0-1)
- •Age > 18 years. Adult patients of all ages, both sexes and all races will be included in this study. Female patients within reproductive years may not be, nor become, pregnant during participation in this study
- •life expectancy > 3 months
排除标准
- •patients with active hepatitis or clinically significant liver failure
- •patients receiving anticoagulation treatment with warfarin or heparin
- •prior radiation therapy to the right upper abdomen, precluding re-irradiation of the liver
- •clinically apparent ascites
- •central nervous system metastases
结局指标
主要结局
To evaluate feasibility of conformal radiation therapy in patients with metastatic colorectal liver cancer and determine its safety
次要结局
- To evaluate local control rate within irradiated fields
- To assess failure patterns and survival of patients treated with conformal liver radiation
- Set up verification with cone-beam CT (OBI on Boar Imager)
研究者
研究点 (2)
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