NCT05967832招募中不适用
Contribution of 7 Tesla MRI of the Hypothalamus in the Diagnosis of Type 1 Narcolepsy: Pilot Study
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Hypothalamic morphological difference
研究概览
简要总结
This study is part of the research on type 1 narcolepsy, a neurological pathology affecting mostly young subjects. The only biomarker currently available is the hypocretin assay, which shows a level below 110 pg/mL. However, the interpretation of this biomarker has limitations: the test is not widely available and it is rarely performed by practitioners. Even when performed, the interpretation of the level may not be consistent with the phenotype compatible with type 1 narcolepsy.
This study therefore aims to develop new tools to reduce the diagnostic delay. This would be the first study with 7T MRI that could achieve a level of spatial resolution sufficient to highlight volume changes in small brain structures such as the lateral hypothalamus whose narcolepsy-induced changes are not detected by lower resolution MRI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for patients :
- •Diagnosis of narcolepsy type 1 according to the diagnostic criteria of the International Classification of sleep disorders version 3 (ICSD-3, American Academy of Sleep Medicine, 2014) including a mean sleep latency of less than 8 minutes on the iterative sleep latency test associated with at least two direct REM sleep onset and the presence of cataplexy, and a cerebrospinal fluid hypocretin assay of less than 110 pg/ml performed by the reference radioimmunology (RIA) technique.
- •Patient at least 18 years old
- •Patient followed at the Narcolepsy and Rare Hypersomnias Competence Center, Timone Hospital, Marseille
- •Patient having signed an informed consent
- •Patient who is a beneficiary of or affiliated to a social security system
排除标准
- •for patient:
- •Diagnosis of type 1 narcolepsy according to ICSD-3 criteria but without hypocretin assay
- •Narcolepsy secondary to another neurological pathology or presence of a comorbid neurological pathology (multiple sclerosis, Steinert's myotonic dystrophy, head trauma, epilepsy)
- •Protected patient: pregnant or breastfeeding woman, adult under guardianship or curatorship
- •Contraindication to the realization of a 7T MRI: patient wearing a pacemaker, neurosurgical clips, artificial heart valve, surgical material or metal fragments in the body, dental or hearing prostheses, insulin pump, patient wearing an IUD, claustrophobic patient
- •Patient unable to maintain decubitus position for the duration of the MRI (= 50 minutes)
- •Inclusion criteria for healthy volunteers:
- •Subject 18 years of age or older
- •Subject free of general illness, psychiatric disorders, and infectious, inflammatory, tumor, vascular, degenerative, or traumatic pathology of the central nervous system as determined during the medical interview.
- •Subject who has signed an informed consent ;
- •Subjects who are beneficiaries of or affiliated with a social security plan
- •Exclusion criteria for healthy volunteers:
- •Protected subject: pregnant or breastfeeding woman, adult under guardianship or curatorship
- •Subjects presenting a contraindication to the realization of a 7T MRI: patient with a pacemaker, neurosurgical clips, artificial heart valve, surgical material or metal fragments in the body, dental or auditory prostheses, insulin pump, patient with an IUD, claustrophobic patient
- •Subject unable to maintain a decubitus position for the duration of the MRI (= 50 minutes)
研究组 & 干预措施
Patients with type 1 narcolepsy
Experimental
Patients with type 1 narcolepsy
干预措施: 7T MRI (Other)
Healthy volunteers
Active Comparator
干预措施: 7T MRI (Other)
结局指标
主要结局
Hypothalamic morphological difference
时间窗: Month 0
Significant structural size difference between right and left lateral hypothalamus
次要结局
- Structural changes in hypothalamic nuclei other than the lateral hypothalamus(Month 0)
- Microstructural abnormalities other than volume differences(Month 0)
研究者
研究点 (1)
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