A prospective randomized comparative trial to evaluate the best time-point to taper-off anticonvulsive medication after epilepsy surgery
Not Applicable
- Conditions
- G40.2Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
- Registration Number
- DRKS00021608
- Lead Sponsor
- niversitätsklinikum Göttingen Klinik für Anästhesiologie Klinik für Klinische Neurophysiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Resective epilepsy surgery
- preoperative seizure frequency = 1 seizure per month
- immediate postoperative seizure freedom for at least 3 months
Exclusion Criteria
- Epileptic seizures within the first 3 months after epilepsy surgery
- Participation in a clinical trial on an anticonvulsive drug
- Pregnancy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of patients per group (tapering off medication 3 months vs. 12 months after epilepsy surgery) who are seizure-free 24 months after epilepsy surgery without anticonvulsive medication
- Secondary Outcome Measures
Name Time Method - Number of patients per group (tapering off medication 3 months vs. 12 months after epilepsy surgery) who are seizure-free 24 months after epilepsy surgery with anticonvulsive medication<br>- Number of patients per group (tapering off medication 3 months vs. 12 months after epilepsy surgery) who are not seizure-free 24 months after epilepsy surgery with anticonvulsive medication<br>- Time until the first epileptic seizure recurs from begin of reduction of medication onwards<br>- Number of patients suffering a relapse during the time of tapering medication<br>- Clinical factors associated with the reoccurrence of epileptic seizures