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临床试验/NCT02361372
NCT02361372已完成不适用

Short-term Effect of Kefir-fermented Milk Consumption on Bone Mineral Density and Bone Metabolism in Osteoporotic Patients

Ministry of Science and Technology, Taiwan0 个研究点目标入组 69 人开始时间: 2010年5月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
69
主要终点
bone mineral density and bone regeneration

研究概览

简要总结

In a controlled, parallel, double-blind intervention study over 6 months, the investigators investigated the effects of kefir-fermented milk (1,600 mg/kg) supplemented with calcium bicarbonate (CaCO3, 1,500 mg/kg) and bone metabolism in 40 osteoporosis patients, and compared them with CaCO3 alone without kefir supplements. Bone turnover markers were measured in fasting blood samples collected before therapy and at 1, 3, and 6 months. BMD values at the spine, total hip, and hip femoral neck were assessed by dual-energy x-ray absorptiometry (DXA) at baseline and at 6 months.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Investigator)

入排标准

年龄范围
55 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Clinical diagnosis of osteoporosis patients

排除标准

  • Any previous use of parathyroid hormone or sodium fluoride, use of anabolic steroids or growth hormone within 6 months before trial entry or oral or intravenous systemic corticosteroids within 12 months, and any previous use of strontium.

结局指标

主要结局

bone mineral density and bone regeneration

时间窗: 3 months

次要结局

未报告次要终点

研究者

发起方
Ministry of Science and Technology, Taiwan
申办方类型
Other Gov
责任方
Principal Investigator
主要研究者

Min-Yu Tu

Ministry of Science and Technology

Ministry of Science and Technology, Taiwan

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