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临床试验/NCT05464134
NCT05464134尚未招募不适用

Incidence of Lumbar Spondylolisthesis in Patients Candidate for Total Knee Replacement

Assiut University0 个研究点目标入组 60 人开始时间: 2023年5月最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
60
主要终点
occurence of lumbar spine spondylolishtesis Occurrence of lumbar spine spondylolisthesis

研究概览

简要总结

This study aims to detect the incidence of spondylolisthesis in patients candidate for Total knee replacement (TKR) and to investigate the effect of TKR on the course of low back pain.

详细描述

Total Knee Replacement (TKR) is one of the most successful surgeries in modern-day orthopedics, performed mainly to treat end-stage knee osteoarthritis (OA) . degenerative spondylolisthesis is one of the most common causes of low back pain where a spinal vertebra slides from its anatomical position, affecting about 11.5% of the population, furthermore, many elderly patients undergoing TKR usually suffer from spondylolisthesis.

Spondylolisthesis with subsequent lumbar spine degenerative disease presents as lower back and radiating pain to the legs at rest or during activity, Spondylolisthesis causes hamstring tightness which is felt as pain at the back of the knee, lumbar radiculopathy of the L3 root nerve could vary from thigh pain to hip and/or knee pain, all of which could be misled as pain due to knee OA . On the other hand, patients having knee OA with a flexion deformity compensate their posture by increasing the lumbar lordosis, if the lumbar spine lost its ability to compensate for the knee deformity, this could aggravate low back pain and enhance further lumbar spine instability and spondylosis .

In addition, the persistence of coexisting lumbar spine symptoms after TKA might adversely affect postoperative outcomes in terms of pain and function, even after successful TKA .

Chang et al., studied the prevalence and severity of coexisting lumbar spondylosis in terms of radiographic lumbar spine degeneration and lumbar spine symptoms in patients with advanced knee OA undergoing TKR, in their study, 51% of patients undergoing TKR had at least one moderate to severe lumbar spine symptom, and patients with severe radicular pain on the activity before the TKR was likely to demonstrate poor knee function 2 years post-TKR . This is why lumbar spine pathologies should be fully investigated in patients coming for TKR.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
40 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • primary end-stage knee osteoarthritis.

排除标准

  • secondary inflammatory knee osteoarthritis.
  • post traumatic knee osteoarthritis.
  • patients with active infection.
  • patients with poor general condition.
  • patients who had previous spinal fixation or fusion surgery.

结局指标

主要结局

occurence of lumbar spine spondylolishtesis Occurrence of lumbar spine spondylolisthesis

时间窗: Baseline

Showing the occurrence of lumbar spine spondylolisthesis in patients with severe osteoarthritis which needs total knee replacement

Incidence of lumbar spine spondylolisthesis.

时间窗: Baseline

showing the incidence and occurrence of Lumbar Spondylolisthesis in patients with severe knee Osteoarthritis which needs Total knee replacement

Severity of lumbar spine spondylolisthesis.

时间窗: Baseline

showing the grades of lumbar spine spondylolisthesis through The Meyerding classification system with grade 1 is the minimum and grade 5 is the maximum which in turn has the worst outcome

次要结局

  • Change in characters of low back pain over the postoperative period.(6 months follow up)
  • Spine radiological features.(Baseline)
  • Knee radiological and alignment features.(Baseline)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mario Sameh Wadie Narouz

Principal Investigator

Assiut University

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