Linking Bioenergetic Phenotypes in Circulating Cells with Cardiometabolic Health in School-age Children
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Platelet mitochondrial respiration and its association with adiposity and peak aerobic capacity in children 8 to 10 years old.
研究概览
简要总结
This research study is about how daily activities, behaviors, and fitness affect the health and function of blood cells and their mitochondria, which are the powerhouses of the cells. These small mitochondria inside the cells make energy, and are very important for the health of the body.
详细描述
Determine the impact of physical activity and obesity status on circulating cells mitochondrial function (e.g., fat vs. carbohydrates combustion capacity, total oxidative capacity, mitochondrial number and proton leak).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 8 Years 至 10 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages 8-10 years Boys and girls All ethnicity All BMI
排除标准
- •severe persistent asthma exercise induced asthma autism spectrum disorder attention deficit hyperactivity disorder attention deficit disorder
- •Opposition defiant disorder
- •conduct disorder
- •chronic kidney disease
- •hormonal disease
- •autoimmune diseases
- •bleeding disorders
- •chronic infections
- •mental health disorder
- •Type 2 and Type 1 diabetes
- •Other pre-existing medical conditions or medications as determined by the investigators to affect the outcomes of interest
结局指标
主要结局
Platelet mitochondrial respiration and its association with adiposity and peak aerobic capacity in children 8 to 10 years old.
时间窗: 8 days
Platelet mitochondrial respiration from isolated platelets will be measured using a flux analyzer. Adiposity will be measured with dual X-ray absorptiometry, and peak aerobic capacity with an incremental cycle ergometer test. measure physical activity
次要结局
未报告次要终点