Can Heart attack patients without coronary artery blockages benefit from standard heart attack medical treatment strategies?

Phase 4

• Conditions: Myocardial Infarction With Non-obstructive Coronary Arteries; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12618001858280
• Lead Sponsor: The University of Adelaide

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-15
• Study Completion: 2023-05-31
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 71

Inclusion Criteria

1. Age equal or greater than 18 years.
2. A clinical diagnosis of MINOCA, including:
a. Acute myocardial infarction – as per the universal myocardial infarction Criteria (Thygesen et al, 2018)
b. Non-obstructive coronary arteries – no lesion equal or greater than 50% in the potential infarct-related artery.
c. No overt non-ischaemic cause for the acute clinical presentation.
3. Left ventricle ejection fraction equal or less than 40% - assessed by echocardiography, MRI or left ventriculography prior to
randomisation.
4. Written informed consent obtained

Exclusion Criteria

Any condition that may influence the patient's ability to comply with study protocol.
2. Pregnancy
3. Previous revascularization (CABG or PCI)
4. Myocarditis Diagnosis (Cardiac MRI proved myocarditis or a strong clinical suspicion
of myocarditis as a cause of the index event)
5. Clinical signs of heart failure
6. Contraindications for ACEI and ARB
7. Contraindications for beta-blockers
8. Prior use of ACE-I, ARB, or beta blockers, which must continue as per treating
physician
9. New indication for beta-blockers or ACEI/ARB other than as secondary prevention as
per treating physician.
10. Participation in a trial evaluating a drug known to interact with beta blockers or
ACEI/ARB

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to death of any cause, or time to readmission because of AMI, ischemic stroke or heart failure - A Composite of time to all-cause Death and time to re-admission because of acute myocardial infarction, ischemic stroke or heart failure<br><br><br>1) Death (any cause) will be obtained from the hospital/medical or administrative records.<br>2) Acute myocardial infarction, ischemic stroke, heart failure, unstable angina, atrial fibrillation<br>will be obtained from the hospital/medical records and from patient interviews held via telephone.[ Time to event from the date of enrollment through study completion, an average of 4 years.]