NCT05484700Unknown不适用
SARS-CoV-2 Neutralizing Antibodies and Immunity After Vaccination of Recovered Patients With COVID-19 and Correlation With Immunity and Long-COVID-19 Symptoms
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 305
- 试验地点
- 1
- 主要终点
- Anti-SARS-CoV-2 NP
研究概览
简要总结
We investigated the association between immune system responsibilities in Long COVID patients and Full recovery patients.
详细描述
This retrospective cohort study compared immunogenicity post COVID-19 between individuals (aged 18-65 years and had confirmed SARS-CoV-2 infection from January to May 2022 ) with residual Long COVID-19 symptoms (LC) and ones with full recovery (Full) related to pathophysiology, immunology and clinical consequence.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Long COVID group; at longer than 1-month post COVID-19 based the presence of one of the three following symptoms: fatigue/myalgia, breathlessness, and anorexia
- •Full recovery group; patients with asymptomatic symptoms
- •post COVID-19 they had not received any additional COVID vaccine
排除标准
- •people who received additional vaccination after leaving quarantine before the day of the immunization test
- •pregnant patients,
- •people who had a history of allergic reactions after COVID-19 vaccination or any drugs
结局指标
主要结局
Anti-SARS-CoV-2 NP
时间窗: Baseline
surrogate Virus Neutralization Test (sVNT) (PRNT50 titer)
Microneutralization assays
时间窗: Baseline
Microneutralization assays using the authentic SARS-CoV-2 viruses
Anti-SARS-CoV-2 RBD IgG
时间窗: Baseline
anti-SARS-CoV-2 receptor-binding domain immunoglobulin G(BAU/mL)
次要结局
- Number of vaccine injection(Baseline)
- Prevalence of Long COVID-19 symptoms(Baseline)
研究者
研究点 (1)
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