Optimizing Protein Intake and Nitrogen Balance in Adult Critically Ill Patients
- Conditions
- Protein Deficiency
- Interventions
- Dietary Supplement: PROTEIN SUPPLEMENTATION
- Registration Number
- NCT02990065
- Lead Sponsor
- University of Padova
- Brief Summary
The purposes of the study are:
* To strictly ensure the appropriate level of protein and caloric provision in critical illness, according to the latest literature recommendation;
* To determine if an association exists between protein intake and nitrogen balance in the context of a nutrition with appropriate protein provision based on the latest literature recommendations, rather than in a standard diet with a caloric target weight-based. Creatinine clearance will also be evaluated to determine if there is any harmful effect to the kidney secondary to an elevated BUN.
* To determine if there is a difference in ICU mortality rate between the current nutrition standard and a hyperproteic nutrition protocol.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description PROTEIN-FORTIFIED DIET PROTEIN SUPPLEMENTATION The protein-fortified diet consists on an energy goal based on REE measurement and a protein target based on the most recent literature recommendations (1.2-2 g/kg/die) (2). Daily caloric requirement, and subsequent protein content, of patients enrolled in the intervention group will be calculated using formulas in Table 1 (10, 12, 13). For each patient will be calculated the Resting Energy Expenditure (REE) and daily protein requirement (1.2-2g/kg/die of body weight registered at the admission) and the corresponding caloric intake (1g = 4 kcal). Finally, total daily caloric intake will be calculated by adding kcal from protein (1g = 4kcal) on kcal from non-protein (50% of REE).
- Primary Outcome Measures
Name Time Method nitrogen balance (gr) change from baseline through study completion, an average of 15 days (gr)
- Secondary Outcome Measures
Name Time Method