COVID-19 in Liver Transplant Recipients in Spain: a Nationwide Prospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 121
- 试验地点
- 1
- 主要终点
- Incidence of COVID19 in LT recipients
研究概览
简要总结
Prospective observational study aimed at analyzing the incidence, clinical characteristics and outcomes of COVID-19 in LT in Spain.
详细描述
Coronavirus Disease 2019 (COVID-19) is a novel viral disease caused by the SARS-Cov-2 infection with a particular predominance of upper and lower respiratory tract symptoms. First diagnosed in China in late 2019, the virus has progressed to a state of pandemia, involving Spain with a important outbreak.
While the outcomes of viral infections in solid organ transplant (SOT) recipients tend to be worse than those from the general population due to chronic immunosuppression, there is little information on the incidence and outcomes of COVID-19 in liver transplant (LT) recipients. LT recipients are usually under less immunosuppression than other SOT and the clinical expression and outcomes of COVID-19 may be different to the reported outcomes in other SOT.
The Spanish Society of Liver Transplantation, which includes 25 LT programs, has promoted a nationwide registry for LT with COVID-19 to help ascertain the incidence and outcomes and help evidence-based management .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Liver Transplant recipient
- •Confirmed (PCR positive) SARS-Cov-2 infection
- •Informed Consent
排除标准
- 未提供
结局指标
主要结局
Incidence of COVID19 in LT recipients
时间窗: 12 months
Observed treatments and immunosuppression management
时间窗: 12 months
Clinical characteristics of COVID19 in LT recipients
时间窗: 12 months
Survival and Mechanical ventilation / respiratory support
时间窗: 3 months
次要结局
未报告次要终点
研究者
Jordi Colmenero
Liver Transplant Hepatologist, SETH Scientific Committee Chair
Hospital Clinic of Barcelona