Evaluation of Serum Copeptin and Psychological Stress Level Among Healthcare Providers During COVID-19 Pandemic
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- determine stress hormones in serum cortisol and copeptin
研究概览
简要总结
Psychological stress (PSS) is one of the most common problems among healthcare providers during COVID-19 pandemic. PSS influences the homeostatic equilibrium of the body, involving activation of the sympathetic nervous system and hypothalamus pituitary adrenal (HPA) axis. Copeptin; C-terminal portion of Vasopressin (AVP) precursor is stable. Nevertheless, Evidence about influence of PSS on copeptin levels is lacking. The reason we are doing this research is to determine the level of psychological stress among healthcare providers exposed to at the time of work in intensive care unit (ICU) during COVID-19 pandemic; They will be appraised every assembly for psychological stress level; before start of duty shifts (first time), one week after start (second time) and two weeks after departure from shift duties in ICU (third time) for assessment of psychological stress level and stress hormones.
详细描述
A total of 70 healthcare personnel volunteers participated; 35 physicians and 35 nurses. All healthcare providers' volunteers are in good physical health, Exclusion criteria included hypertension, diabetes mellitus, obesity BMI ≥30, subjects with serum sodium ≤135 or ≥ 145 mmol /L at baseline or females receiving contraceptive pills.
During the research participants will answer a questionnaire as well as three blood samples are taken.
- In the first meeting, evaluation of participant general condition; determining BMI, blood pressure. Then a small amount of blood, equal to about two millimeters, will be taken from participant arm with a syringe. This blood will be tested for serum copeptin, cortisol (fasting morning sample). The investigator will ask participant few questions to evaluate the level of stress (as anxiety, insomnia, fear of infection through questionnaire)
- The second meeting, one week after work in ICU, another blood sample will be taken from participant and determine level of psychological stress.
- The third meeting, two weeks after leave from ICU participant blood sample will be taken from participant to determine stress hormones and determine level of psychological stress.
Duration
The research takes place over six months in total.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 24 Years 至 37 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •physicians and nurses under age of 37 years in good health
排除标准
- •body mass index above 30
- •hypertension
- •Diabetes mellitus
- •females receiving contraceptive pills
结局指标
主要结局
determine stress hormones in serum cortisol and copeptin
时间窗: four weeks for each participant..
Second to determine stress hormones copeptin and cortisol (possible stress biomarkers) concurrently with questionnaire.
evaluation of psychological stress
时间窗: four weeks for each participant.
- Primarily outcome determination of psychological stress among doctors and nurses working in ICU through a questionnaire before duty shifts \[first time\] and re-evaluate it after one week of work in ICU \[second time\], and lastly two weeks after departure from shift duties \[third time\].
次要结局
- correlation of psychological stress with stress hormone copeptin(four weeks for each participant..)
研究者
hala mourad demerdash
Consultant Clinical Pathology
Alexandria University