NCT01750710已完成不适用
Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With Neuropathy Charcot-Marie-Tooth Disease Type 1A
University Hospital, Clermont-Ferrand1 个研究点 分布在 1 个国家目标入组 37 人开始时间: 2012年12月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 37
- 试验地点
- 1
- 主要终点
- axonal loss
研究概览
简要总结
This exploratory cross-sectional study proposes, firstly, to objectify in a population of Charcot-Marie-Tooth disease type 1A (CMT 1A)if there is a correlation between the recording of electrical parameters and upper limb muscle strength of the thigh and in a second step, to seek a relationship between the measured parameters.
详细描述
Patients suffering from CMT 1A neuropathy will be invited to go through a series of tests such as:
- Electromyography
- Isokinetic test
- Podiatric assessment
- Functional evaluations: Hand dexterity, limbs muscles strength
- Quality of life assessment with questionnaires
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients older than 18 years
- •Diagnosis of Charcot Marie Tooth disease, type 1A confirmed by molecular biology (duplication 17.p11.2)
- •Listening and written French
- •Agreement after written information, clear and honest about the purpose of the study, the nature of the tests and their possible side effects or bothersome.
- •Strength of the quadriceps superior to 2/5 MMT MRC
排除标准
- •Presence of other neurological comorbidity
- •Presence of coronary artery disease unstabilized
- •Peripheral neuropathy of other causes: diabetes, monoclonal gammopathy, malignancy, solid cancer, systemic autoimmune disease (lupus, Sjögren's disease, Wegener sarcoidosis ...), infectious disease (viral hepatitis, HIV ...), drugs known to be responsible for iatrogenic neuropathy.
- •Gait trouble of other origin
- •Patients unable to give their consent.
- •Intellectual deficit that does not allow to comply with tests
结局指标
主要结局
axonal loss
时间窗: at day 1
次要结局
- Depression(at day 1)
- spatial and temporal parameters of walking(at day 1)
- Barometric stabilometric podo-static scores(at day 1)
- Quality of life(at day 1)
- Muscle strength(at day 1)
- Functional scores(at day 1)
- Hand testing(at day 1)
- Fatigue(at day 1)
研究者
研究点 (1)
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