Efficacy Of Intralesional Injection Of Methotrexate Versus Triamcinolone Acetonid In Treatment Of Localized Psoriasis
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Efficacy Of Intralesional Injection Of Methotrexate Versus Triamcinolone Acetonid In Treatment Of Localized Psoriasis
研究概览
简要总结
The aim of the present study is to evaluate the efficacy of intralesional injection of methotrexate in comparison with Intralesional Injection of Triamcinolone Acetonid in localized psoriasis (body surface area < 10%) .
详细描述
study enrolling 30 patients of localized psoriasis. 15 patients received intralesional methotrexate :
- Taking aseptic condition ,One psoriatic plaque will treated with Intralesional injection of methotrexate (25mg /ml) at dosage of 0.1 ml /cm2.
- Another plaque will treated with intralesional ingection of distilled water as controlled plaque.
- patient will receive oral folic acid 5mg tablet every day except the day of injection.
Other 15 patients received intralesional trimethinolone acetonide:
- Taking aseptic condition , One plaque will treated with Intralesional injection of trimethinolone acetonide (10mg/ml) at dosage of 0.1 ml/ cm2 .
- another plaque will treated with Intralesional injection of distilled water as controed plaque.
- Patients will take 6 sessions every 2 weeks for 3 months and will followed up at 2 month and 3 months after treatment .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 15 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with localized Psoriasis (body surface area<10%)
排除标准
- •Patient refusal. Generalized psoriasis. Pregnancy. Lactation. Immunocompromised patients . Patients with history of hypersensitivity to methotrexate. Patients with other inflammatory skin disorders. Patients with chronic hepatic, renal , pulmonary ,or haematological disorders. patients on treatment for psoriasis .
研究组 & 干预措施
Methotrexate
Intralesional injection of methotrexate
干预措施: Intralesional Injection of Methotrexate (Drug)
Methotrexate
Intralesional injection of methotrexate
干预措施: Triamcinolone Acetonid (Drug)
Triamcinolone Acetonid
Intralesional injection of trimethinolone acetonide
干预措施: Intralesional Injection of Methotrexate (Drug)
Triamcinolone Acetonid
Intralesional injection of trimethinolone acetonide
干预措施: Triamcinolone Acetonid (Drug)
结局指标
主要结局
Efficacy Of Intralesional Injection Of Methotrexate Versus Triamcinolone Acetonid In Treatment Of Localized Psoriasis
时间窗: 3 months after treatment
clinical and dermoscopic changes according to psoriasis area severity index
次要结局
未报告次要终点
研究者
Gehad Hamdy Abdelgaber
Gehad Hamdy
Sohag University