JPRN-UMIN000013000招募中2 期
Phase II study of perioperative chemotherapy (preoperative XELOX+Bevacizumab/ postoperative XELOX) in patients with locally advanced rectal cancer - pedioperative chemotherapy study of XELOX +bevacizumab for locally advanced rectal cancer.(RUDDER Trial)
Sano Hospital Masahito Kotaka, MD0 个研究点目标入组 50 人开始时间: 2014年1月28日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 80years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1. Need to drain malignant coelomic fluid; 2.Multiple primary cancer within 5years 3. Bleeding tendency, coagulation factor or abnormal clotting disorder (INR 1.5) 4. Intestinal paralysis, intestinal obstruction, peptic ulcer uncontrollable 5.Serious complications (diabetes, infections, diarrhea) 6. Symptomatic or asymptomatic but treated heart disease. History of those within one year prior to enrollment 7. History of the serious hypersensitivity for fluorouracil, platinum compound. History of adverse events related to DPD loss 8. Peripheral sensory neuropathy (CTCAE v4.0 Grade 1); 9.Pulmonary fibrosis or interstitial pneumonia 10. Current or previous (within the last 1 year) history of cerebrovascular disease 11.Administered antithrombotic agents for thrombosis within 10 days prior to enrollment 12. Serious hypertension 13. History of gastrointestinal perforation 14.Pregnant women,possibly pregnant women, wishing to become pregnant, and nursing mothers; 15.No intention to practice birth control; 16.Previously treated with oxaliplatin;or capecitabine 17.Any other medical conditions disable to comply with the protocol
研究者
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