Investigation of Efficiency of Breathing With Different Breathing Patterns in Healthy Volunteers and Patients With Respiratory Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Determining the anatomic dead space change at variable tidal volumes with four different breathing patterns (nose-in and nose-out, mouth-in and mouth-out, nose-in and mouth-out, mouth-in and nose-out) in healthy volunteers.
研究概览
简要总结
Our aim in this study is to investigate the efficiency of the breathing with different breathing patterns. Ten volunteers and twenty patients having respiratory problems will be coached on their breathing through specific masks which will provide four different breathing patterns. These patterns will be 1) Breathing in through the nose only and out through the mouth only 2) Breathing in through the mouth only and out through the nose only 3) Breathing in and out through the nose only 4) Breathing in and out through the mouth only The data obtained from volunteers and patients will be compared within and between the groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For healthy subjects:
- •Ten healthy adult (> 18 years of age) volunteers will be recruited from the MGH main campus through intra-hospital e-mail broadcasting. Subjects with the following issues will be excluded from the study.
- •For patients with respiratory insufficiency:
- •Twenty adult (> 18 years of age) patients will be recruited. These patients will be either patients in acute respiratory failure resulting from COPD exacerbation breathing spontaneously only receiving nasal oxygen admitted to the medical floors of the MGH; or patients with diagnosed stable COPD on home oxygen therapy seen by pulmonary physicians in the outpatient clinics or coming to the MGH as study subjects.
排除标准
- •For healthy volunteers:
- •Subjects with facial deformity, heavy beard or moustache which prevents good seal between the mask and the face;
- •Subjects who have claustrophobia and cannot wear the mask.
- •For patients with respiratory insufficiency:
- •Patients with facial deformity, heavy beard or moustache which prevents a good seal between the mask and the face;
- •Patients who have claustrophobia and cannot wear the mask.
- •Patients who are hemodynamically unstable.
- •Patients requiring continuous noninvasive positive pressure ventilation or endotracheal intubation.
研究组 & 干预措施
Volunteers
Ten healthy volunteers
干预措施: Breathing Patterns (Other)
Patients
Sixteen patients with respiratory insufficiency
干预措施: Breathing Patterns (Other)
结局指标
主要结局
Determining the anatomic dead space change at variable tidal volumes with four different breathing patterns (nose-in and nose-out, mouth-in and mouth-out, nose-in and mouth-out, mouth-in and nose-out) in healthy volunteers.
时间窗: 3 months
Comparing the efficiency of CO2 removal at given minute ventilations with the four different breathing patterns in patients with chronic respiratory failure.
时间窗: 6 months
次要结局
- Comparing the efficiency of the study mask which forces subjects to breathe in a manner similar to pursed lip breathing and a regular facemask in healthy volunteers and patients with respiratory failure(6 months)
研究者
Yandong Jiang
Assistant Professor of Anesthesia
Massachusetts General Hospital