Stereotactic body radiotherapy for stage I non-small-cell lung cancer using higher doses for lager tumors: employing escalated doses
- Conditions
- primary lung cancer
- Registration Number
- JPRN-UMIN000027231
- Lead Sponsor
- Department of Radiology, Nagoya City University Graduate School of Medical Sciences
- Brief Summary
Background Efficacy of stereotactic body radiotherapy (SBRT) in stage I non-small-cell lung cancer (NSCLC) has almost been established. In Japan, the protocol of 48 Gy in 4 fractions over 4 days has been most often employed, but higher doses may be necessary to control large tumors. Previously, we conducted a clinical study using SBRT for stage I NSCLC employing different doses depending on tumor diameter, which was closed in 2008. Thereafter, a new study employing higher doses has been conducted, which is reported here. The purpose of this study was to review the safety and effectiveness of the higher doses. Methods We escalated the total dose for the improvement of local control for large tumors. In this study, 71 patients underwent SBRT between December 2008 and April 2014. Isocenter doses of 48, 50, and 52 Gy were administered for tumors with a longest diameter of < 1.5 cm, 1.5-3 cm, and > 3 cm, respectively. It was recommended to cover 95% of the PTV with at least 90% of the isocenter dose, and in all but one cases, 95% of the PTV received at least 80% of the prescribed dose. Treatments were delivered in 4 fractions, giving 2 fractions per week. SBRT was performed with 6-MV photons using 4 non-coplanar and 3 coplanar beams. Results The median follow-up period was 44 months for all patients and 61 months for living patients. Overall survival (OS) was 65%, progression-free survival (PFS) was 55%, and cumulative incidence of local recurrence (LR) was 15% at 5 years. The 5-year OS was 69% for 57 stage IA patients and 53% for 14 stage IB patients (p = 0.44). The 5-year PFS was 55% and 54%, respectively (p = 0.98). The 5-year cumulative incidence of LR was 11% and 31%, respectively (p = 0.09). The cumulative incidence of Grade 2 radiation pneumonitis was > 25%. Conclusions Our newer SBRT study yielded reasonable local control and overall survival and acceptable toxicity, but escalating the total dose did not lead to improved outcomes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 70
Not provided
(1)No serious diabetes, collagen disease, cardiac disease, pulmonary disease, kidney disease and psychological disorder. (2)Single lung. (3)Receiving home oxygen therapy. (4)Pregnant or lactating woman, likelihood of pregnancy. (5)Active infectious disease. (6)Implanted pacemaker or implantable cardioverter defibrillator. (7)No history of thoracic radiation therapy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method overall survival rate
- Secondary Outcome Measures
Name Time Method progression-free survival rate, local control rate, adverse event