Direct Evaluation of Postoperative Myocardial Injury using Coronary Computed Tomography Angiography after Non-Cardiac Surgery

Completed

Conditions: 1.pulmonary embolism
2. coronary artery disease
10011082
10014523

Registration Number: NL-OMON47220

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 354

Inclusion Criteria

-* 60 years old
-Major noncardiac surgery, defined as non-cardiac surgical procedures requiring hospital admittance > 24 hours
-(Semi-)elective surgery, defined as surgery that that has been preceded by a preoperative evaluation.
-* 1 troponin assessment in the first 3 postoperative days as a part of the routine *postoperative troponin assessment* protocol.
-For patients who undergo surgery more than once, the first surgery will be included in the analysis. Reoperations will not be included.

Exclusion Criteria

-Typical angina
-Acute ST-elevation myocardial infarction (STEMI) or new left bundle branch block (LBBB) on ECG
-Patients unable to fully comply to study needs (e.g. incompetent patients or patients unable to communicate in Dutch or English)
-Severe claustrophobia.
-Patients who have a life expectancy of less than three months.
-Patients who are too ill to undergo a CCTA or Ventilation/Perfusion (V/Q) scan.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Pulmonary embolism (PE) on either Coronary Computed Tomography Angiography<br /><br>(CCTA) or Ventilation/Perfusion (V/Q) scan. PE on CCTA is defined as a sharply<br /><br>delineated pulmonary artery filling defect in at least two consecutive image<br /><br>sections of the CCTA, either located centrally within the vessel or with acute<br /><br>angles at its interface with the vessel wall. PE on V/Q scan is defined as at<br /><br>least one segmental or two subsegmental perfusion defects without corresponding<br /><br>abnormality on chest X-ray. </p><br>

Secondary Outcome Measures