Dynamic Variation of Impedance Cardiography (ICG) a Diagnostic Tool of Acute Heart Failure (AHF) in Emergency Department (ED) Patients Admitted for Acute Dyspnea
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Cardiac output variation measured by ICG before and after nitroglycerin in acute dyspneic patients between the AHF and non AHF groups
研究概览
简要总结
the study aimed to evaluate the diagnostic performance of cardiac output (CO) change after the use of trinitrine in the diagnosis of heart failure patients with acute dyspnea.
详细描述
Acute heart failure (AHF) is a frequent condition in emergency department and is responsible of high number of admissions, complications, and deaths.
despite advances in diagnostic techniques, AHF diagnosis still be challenging .
Measurement of cardiac output (CO) is used to evaluate global cardiac function and changes in CO may be used to identify a change in the hemodynamic status of patient.
the gold standard of measuring CO is thermodilution catheterization, however it is an invasive technique with high risks.
Impedance cardiography (ICG) is a noninvasive method for measuring CO. it is performed by applying small electrical current to the chest through electrodes placed on the neck and sides.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 year old or above non traumatic acute dyspnea
排除标准
- •ECG diagnostic for acute myocardial infarction or ischemic chest pain within the prior 24 hours,
- •pericardial effusion ,
- •chest wall deformity suspected of causing dyspnea,
- •need for mechanical ventilation or vasopressor drugs,
- •serious and sustained arrhythmia,
- •pace maker,
- •severe mitral valve disease, severe pulmonary arterial hypertension,
- •renal failure (creatinine >350µmol/l.
结局指标
主要结局
Cardiac output variation measured by ICG before and after nitroglycerin in acute dyspneic patients between the AHF and non AHF groups
时间窗: 24 hours
the diagnostic performance is evaluated by calculating the CO in ml/min by bio-impedance technique and compare the values between patients with and without AHF and between baseline.
Sensitivity, specificity, positive and negative predictive values, and likelihood ratios of positive and negative results were calculated using the optimal cutoff value of deltaCO.
时间窗: 24 hours
Sensitivity, specificity, positive and negative predictive values, and likelihood ratios of positive and negative results were calculated using the optimal cutoff value of deltaCO.
roc curve
时间窗: 24
Receiver operating characteristic (ROC) curves for predicting HF were constructed and area under curve (AUC) was measured for the deltaCO.
次要结局
未报告次要终点
研究者
Pr. Semir Nouira
professor semir nouira
University of Monastir