Effect of intra- and postoperative strategy of pain management on functional outcome in patients subjected to total knee arthroplasty (TKA)

Conditions: total knee arthroplasty
10023213
10005944

Registration Number: NL-OMON32063

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 90

Inclusion Criteria

Informed consent, American Society of Anesthesiologists (ASA) classification I to III, age older than 18 years

Exclusion Criteria

no informed consent, ASA classification IV or V, infection near the insertion side, coagulation disorder, allergy to local anesthetics, pre-existing neurologic dysfunction, prior vascular surgery near the insertion side, inability to understand the patient controlled analgesia device, pregnancy or lactation period, known hepatic or renal insufficiency, age < 18 years.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Reaching of discharge criteria (90 degree flexion of the knee, no infection,<br /><br>pain on the visual analogue scale (VAS) lower than 4 (scale 0-10)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. functional results at discharge and after 6 weeks and one year after the<br /><br>operation, 2. Analgesic consumption: use of morphine and tramadol, pain<br /><br>measured by VAS postoperatively on day 0, 1, 2 and 3 during rest and movement,<br /><br>respectively, 3. Postoperative nausea and vomiting (PONV, 0: absence, 1: mild,<br /><br>2: severe), 4. Effect of removing catheters on functional aspects (loss of<br /><br>functional capacity after removing catheters), 5. Patient overall satisfaction<br /><br>(measured using the Oxford knee questionnaire, a score with good reliability,<br /><br>content validity and construct validity in patients subjected to<br /><br>TKA15;16)Patient satisfaction with regional blockade procedure (school marks),<br /><br>6. Time necessary to place catheters, 7. Amperage of stimulation of motor<br /><br>response, 8. Onset of motor and sensory block</p><br>