Effect of drugs on blood sugar levels in prediabetic hypertensive patients
- Conditions
- Health Condition 1: null- PRE-DIABETICS with HYPERTENSIO
- Registration Number
- CTRI/2015/06/005886
- Lead Sponsor
- MAMATA GENERAL HOSPITA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 70
• Age >= 18 years and <=75 years of either gender
• Systolic blood pressure >= 140 and/or diastolic blood pressure >= 90 mmHg,
• Patients on monotherapy of ACE-inhibitors / Angiotensin II-receptor blockers for the control of their blood pressure.
• Impaired glucose tolerance with blood glucose levels between 140 â?? 200 mg/dl in oral Glucose Tolerance Test (Oral GTT)
• Previous or current antidiabetic medications
• Patients with higher blood glucose levels > 200mg/dl, with overt diabetes
• Brittle pre-diabetic patients in whom the physician anticipates to initiate antidiabetic medications within next 6 months
•Hypertensive patients in whom the physician anticipates to start polytherapy within next 6 months
• Female patients who are pregnant or nursing or planning pregnancy within the duration of the study
• Suspected or known secondary cause of hypertension.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The effect of ACE Inhibitors /ARBs on blood glucose level in hypertensive pre- diabetic patients by periodic Glucose Tolerance Test (GTT).Timepoint: 1 BASELINE <br/ ><br>2 SIX MONTHS <br/ ><br>3 TWELVE MONTHS
- Secondary Outcome Measures
Name Time Method The exclusive role of RAS blockade, if any, in relation to other contributing factors such as Age, Sex, BMI, Blood pressure which may have confounding effect on the outcome.Timepoint: 1 BASELINE <br/ ><br>2 SIX MONTHS <br/ ><br>3 TWELVE MONTHS