Onderzoek naar de bijwerkingen en immuunrespons na een boostervaccinatie tegen polio, toegediend met een naaldloze Jet Injector.
Completed
- Conditions
- poliomyelitis, polio, vaccination, vaccinatie, intradermal, intradermaal, jet injector, needle-free, naaldloos
- Registration Number
- NL-OMON26044
- Lead Sponsor
- etherlands Vaccine Institute RIVM, formerly Nederland Vaccine, Institute (NVI)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
1. Age ¡Ý 18 years;
2. Good health according to the investigator;
Exclusion Criteria
1. IPV booster dose after 10 years of age;
2. OPV dose;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Safety of injection of IPV with jet injector and of intradermal injection of IPV (local and system reactions);<br /><br>2. Immunogenicity of intradermal injection of reduced dose IPV versus intramuscular injection of full dose IPV (neutralizing antibody titers in serum).
- Secondary Outcome Measures
Name Time Method Immunogenicity (Neutralizing IgA titers) in saliva and the number of poliospecific IgA-producing B cells in peripheral blood.