Using the Roots of a Non Restorable Wisdom Tooth as a Block for Augmentation of Localized Defects

Phase 4

• Conditions: Augmentation

• Registration Number: NCT04266652
• Lead Sponsor: Ain Shams University

Brief Summary

assess and compare the efficacy and safety of autogenous tooth roots for lateral alveolar ridge augmentation with staged implant placement in comparison to autogenous bone block.

Detailed Description

A total of 14 patients in need of implant therapy and lateral ridge augmentation were allocated to parallel groups receiving either 1) healthy autogenous tooth roots (e.g. retained wisdom or impacted teeth or 2) cortical autogenous bone blocks harvested from the retromolar area. After 26 weeks of submerged healing the horizontal bone gain were assessed both clinically and radiographically. A core biopsy was taken during the implant placement to assess the histology of the newly formed bone.

Study Timeline

• Study Start: 2018-01-06
• Study First Submitted: 2020-01-29
• Study First Submitted QC: 2020-02-11
• Study First Posted: 2020-02-12
• Status Verified: 2020-07
• Last Update Submitted: 2020-07-21
• Last Update Posted: 2020-07-22
• Primary Completion: 2020-08-15
• Study Completion: 2020-09-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

1. Candidate for lateral ridge augmentation
2. Insufficient bone ridge width at the recipient site for implant placement
3. Sufficient bone height at the recipient site for implant placement
4. Healthy oral mucosa, at least 3 mm keratinized tissue.
5. Presence of wisdom teeth free from periapical infection.
6. Missing maxillary or mandibular tooth with moderate horizontal defect (4-8) according to cologne classification

Exclusion Criteria

• 1. Patients are systemically free according to Modified Cornell Medical Index 2) smokers patients. 3) Pregnant or lactating women.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Clinical and radiographic assessment of alveolar bone width following autogenous tooth roots augmentation.	6 months postoperatively

Secondary Outcome Measures

Name	Time	Method
Histological analysis of remodeled autogenous bone roots 4 months following horizontal ridge augmentation. Histological analysis of remodeled autogenous bone roots 4 months following horizontal ridge augmentation.	6 months postoperatively

Trial Locations

Locations (1)

Ain Shams University; 🇪🇬 Cairo, Abbassia, Egypt