Evaluation of pretreatment with Lignocaine,Dexmedetomidine or Ketamine in providing relieffrom Propofol injection pain and withdrawalmovements during induction of Anaesthesia
Trial Snapshot
- Phase
- Unknown
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 135
- Locations
- 1
- Primary Endpoint
- during induction of anaesthesia, using lignocaine, dexmedetomidine or ketamine as
Study Overview
Brief Summary
1.To study the degree of alleviation of pain and withdrawal movements, with propofol injection during induction of anaesthesia, using lignocaine, dexmedetomidine or ketamine as pretreatment.
2.To study the variations in haemodynamic parameters.
HYPOTHESIS : Pretreatment with dexmedetomidine would be comparable to ketamine and lignocaine in providing relief from pain and withdrawal movements associated with propofol injection during induction of anaesthesia.
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 65.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •ASA grade I & II
- •BMI less than or equal to 30 kg/m2
- •undergoing elective surgical procedures under general anaesthesia with endotracheal intubation.
Exclusion Criteria
- •History of pulmonary, renal, hepatic, endocrine, neurological or cardiovascular disease(including hypertension, those on beta blockers or digitalis),patients on any sedatives, anxiolytics or analgesics, history of drug abuse and psychiatric illness, known hypersensitivity to the study drugs.
- •Pregnant and nursing females and emergency surgical procedures.
- •Subjects with anticipated difficulty in venous access.
Outcomes
Primary Outcomes
during induction of anaesthesia, using lignocaine, dexmedetomidine or ketamine as
Time Frame: At the time of induction.
To study the degree of alleviation of pain and withdrawal movements, with propofol injection
Time Frame: At the time of induction.
pretreatment.
Time Frame: At the time of induction.
Secondary Outcomes
- To study the variations in haemodynamic parameters.(At the time of induction, preintubation , intubation and post intubation.)