Role of alpha and beta cell secretory function in predicting hypoglycemia in patients with Diabetes Mellitus: A hospital based pilot study

Hypoglycemia is a majorlimiting factor in Insulin initiation in patients with Diabetes Mellitus.Regulation of blood glucose depends on a fine balance between serum insulin andserum glucagon. With this study we intend to see if baseline serum C-peptide(for endogenous beta cell function) and serum glucagon (for alpha cellfunction) can predict the risk of hypoglycemia in insulin treated DM patients.After enrolment in the study and due consent, we will be drawing samples at 0,1h and 3h after a standard meal to assess blood glucose, serum C-peptide andserum glucagon on the first contact with the subject. On the same day, acontinuous glucose monitoring device will be applied on the arm of the subject.The patient will be called for follow up after 14 days for removal of thedevice and recording the data of the device. The frequency of hypoglycemiaepisodes will be correlated with their basal C-peptide and glucagon levels.