Clinical Outcome of Intra Articular Injection of Autologous Platelet Rich Plasma in Anterior Cruciate Ligament Injury.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Visual Analog Scale (VAS ): Change in pain intensity measured by Visual Analog Scale
研究概览
简要总结
This clinical trial will evaluate the effectiveness of platelet-rich plasma (PRP) injections for patients with anterior cruciate ligament (ACL) injury. ACL injuries commonly cause knee instability, pain, and reduced function, and rehabilitation alone may not fully restore recovery in all patients. PRP is prepared from a small sample of the patient's own blood and contains natural growth factors that may promote healing and improve joint function.
In this study, participants will be randomly assigned to one of two groups. The experimental group will receive a single ultrasound-guided injection of PRP into the knee joint along with a standard rehabilitation program. The control group will receive the rehabilitation program alone.
Participants will be followed up at 3 weeks, 8 weeks, and 16 weeks after treatment. At each follow-up visit, knee function, pain level, and physical performance will be assessed using validated outcome measures. The primary aim is to determine whether PRP provides additional benefit compared with rehabilitation alone in improving function and reducing symptoms in ACL-injured patients.
This study will provide new evidence about the role of PRP in ACL management, which may help guide future treatment decisions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Group A/Experimental group
Will receive PRP and conventional conservative method (physical therapy, functional bracing, lifestyle modification)
干预措施: conventional conservative method (physical therapy, functional bracing, lifestyle modification) (Other)
Group B/Control group
Will receive conventional conservative method (physical therapy, functional bracing, lifestyle modification) only
干预措施: conventional conservative method (physical therapy, functional bracing, lifestyle modification) (Other)
Group A/Experimental group
Will receive PRP and conventional conservative method (physical therapy, functional bracing, lifestyle modification)
干预措施: PRP injection (Biological)
结局指标
主要结局
Visual Analog Scale (VAS ): Change in pain intensity measured by Visual Analog Scale
时间窗: Baseline, 3 weeks, 8 weeks, and 16 weeks after intervention.
Pain intensity will be assessed using the Visual Analog Scale (0 = no pain, 10 = worst possible pain).
次要结局
- KOOS: Change in functional outcome measured by Knee Injury and Osteoarthritis Outcome Score (KOOS)(Baseline, 3 weeks, 8 weeks, and 16 weeks after intervention.)
研究者
Isfath Fauzia
Resident
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh