rTMS in Treatment of Obsessive Compulsive Disorder (OCD)
Not Applicable
Completed
- Conditions
- Obsessive Compulsive Disorder
- Interventions
- Device: sham (placebo)Device: repetitive transcranial magnetic stimulation
- Registration Number
- NCT00616486
- Lead Sponsor
- Queen's University
- Brief Summary
Low frequency (1Hz) rTMS applied bilaterally and simultaneously over SMA for 6 weeks in addition to the standard treatment regimen for OCD, will lead to significant improvement in patients' symptoms. The clinical improvement detected by YBOCS, CGI and SF-36 QOLS scores will be statistically significant in active treatment group compared to sham (placebo) treatment group.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
- signed patient informed consent;
- primary obsessive compulsive disorder;
- YBOCS score at least 20;
- males/females 18-65yrs;
- treated with adequate dose of SSRI at least 8 weeks at some stage of illness;
- currently using adequate, stable dose of SSRI at least 4 weeks but not responding.
Exclusion Criteria
- schizophrenia, other psychotic disorders, bipolar I, current major depressive disorder (HDRS(17)>18, substance/alcohol dependence within last 6 months;
- severe axis II;
- suicidal score>=6 on MINI;
- metallic implant in cranium;
- severe/unstable medical conditions;
- not responding to ECT or had TMS in last 6 months;
- history epilepsy;
- neurological disorder leading to increased intracranial pressure;
- severe cardiac disorder/intracardiac lines, pacemakers;
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 sham (placebo) - 1 repetitive transcranial magnetic stimulation -
- Primary Outcome Measures
Name Time Method Yale-Brown Obsessive Compulsive Scale (YBOCS) pre, week 1, 2, 4, 6, 8, 12
- Secondary Outcome Measures
Name Time Method Clinical Global Impression pre, week 1, 2, 4, 6, 8, 12 Hamilton Depression Rating Scale-21(HDRS) pre, week 1, 2, 4, 6, 8, 12 Hamilton Anxiety Rating Scale (HARS) pre, week 1, 2, 4, 6, 8, 12 Visual Analogue Scale pre, week 1, 2, 4, 6, 8, 12 Pittsburgh Sleep Quality Index (PSQI) pre, week 1, 2, 4, 6, 8, 12 SF-36 QOLS version (1) pre, week 1, 2, 4, 6, 8, 12
Trial Locations
- Locations (3)
Military Medical Academy
🇧🇬Sofia, Bulgaria
Providence Care, Mental Health Services
🇨🇦Kingston, Ontario, Canada
Dokuz Eylul University
🇹🇷Izmir, Turkey