MURIM: MUltidisciplinary Research on Implantation failure and Miscarriage

Recruiting

• Conditions: infertility; Subfertility; 10013356

• Registration Number: NL-OMON56176
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 249

Inclusion Criteria

Repeated implantation failure
- Female aged 18-38 years old
- Repeated implantation failure (RIF) defined as:
- failure of implantation of three high quality embryo*s or after placement of
ten or more embryo*s in multiple transfers
- Primary or secondary infertility
- Written informed consent

Recurrent miscarriages
- Female aged 18-38 years old
- Repeated, unexplained miscarriages (RM) defined as 2 or more unexplained
miscarriages not caused by abnormal parental karyotype, maternal thrombophilia
and/or uterine abnormalities
- Written informed consent

Control
- Female aged 18-38 years old
- Uneventful previous pregnancy defined as no preterm delivery, pre-eclampsia
or fetal growth restriction and live birth OR presumed fertile defined as an
indication for PESA/TESE, female sterilisation, or PGD indication for genetic
analysis without subfertility treatment
- Written informed consent

Exclusion Criteria

Repeated implantation failure
- Clinically relevant intra-uterine pathology
- BMI > 35 kg/m2
- Untreated endocrine abnormalities
- PGD treatment

Recurrent miscarriages
- Current or recent (<3 months ago) pregnancy, breastfeeding or hormonal
contraceptive
- Current symptomatic genital infection
- BMI > 35 kg/m2

Control group
- Recurrent miscarriages or repeated implantation failure
- Current or recent (<3 months ago) pregnancy, breastfeeding or current
hormonal contraceptive use
- BMI > 35 kg/m2
- Severe endometriosis (3th -4th degree)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are steroid profile in endometrial tissue and serum,<br /><br>activity of steroid enzymes, phenotype and function of Natural Killer cells,<br /><br>presence of HLA antibodies, determination of the vaginal microbiome and<br /><br>volatile organic compounds.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>