Imaging the neurodevelopmental consequences of intrauterine exposure to Antipsychotics and Lithium
Completed
- Conditions
- Concequences of intrauterine exposure to lithium or antipyschotics1002690810037173
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 441
Inclusion Criteria
Children born between 2003-2012:
- Children of mothers treated with antipsychotics or lithium during pregnancy
- Children of mothers diagnosed with one of the following disorders during pregnancy: bipolar disorder, schizophrenia, schizoaffective disorder, psychosis NOS or borderline personality disorder. - Children of mothers who developed postpartum psychosis (PP) after childbirth.
- Children of women who developed schizophrenia within five years postpartum.
Exclusion Criteria
Children will be excluded if they were exposed to both lithium and antipsychotics in utero, or if their mother used recreational drugs or antiepileptic medication during pregnancy.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>A Magnetic Resonance Imaging (MRI) brain scan will be performed in children<br /><br>aged 8 years or older at the research location. MR images are required on a 3<br /><br>Tesla scanner. The scanning protocol will contain a whole-brain structural MRI<br /><br>examination combined with Diffusion Tensor Imaging (DTI) and functional MRI<br /><br>(fMRI). Primary measures will include: intracranial volume, total brain<br /><br>volume, total gray and white matter, volumes of the four cortical lobes and<br /><br>subcortical structures, cerebellar volume, ventricular volume and cortical<br /><br>thickness. Maps of fractional anisotropy will be calculated (DTI). </p><br>
- Secondary Outcome Measures
Name Time Method