Paramedic-administered pain relief comparing ketamine and morphine in trauma

Phase 3

Completed

• Conditions: Analgesia; Not Applicable

• Registration Number: ISRCTN14124474
• Lead Sponsor: niversity of Warwick

Brief Summary

2023 Protocol article in https://pubmed.ncbi.nlm.nih.gov/38001541/ (added 27/11/2023)

Detailed Description

Not available

Study Timeline

• Study Start: 2020-10-22
• Study Completion: 2023-11-30
• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 458

Inclusion Criteria

1. Age =16 years
2. Patient reports a pain score =7/10 on a 0-10 NRS following acute traumatic injury
3. Vascular access obtained
4. Determined by a paramedic to require IV morphine or equivalent

Exclusion Criteria

1. Known or suspected pregnancy
2. Unable to articulate severity of pain using the 0-10 NRS
3. Lack of capacity due to a reason other than pain
4. Ketamine or opioid analgesia prior to randomisation
5. Contraindication to either ketamine or morphine*
6. Patient declines participation
7. Known prisoner

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effectiveness of pain relief from randomisation to arrival at hospital as measured by Sum of Pain Intensity Difference (SPID) score (using a 0-10 numerical rating scale); Timepoint(s): Arrival at hospital.