Effects of Yoga on Redox Status, Motor Function and Psychosocial Well-being in Individuals With Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Redox status
研究概览
简要总结
The study's purpose is to assess the effect of yoga on measures of oxidative stress (i.e. reduction-oxidation [redox] status); motor function; and psychosocial well-being, and the feasibility and acceptability of implementing a Hatha yoga program in PD subjects.
详细描述
The specific aims of this study are:
Aim 1: Determine the effect of a 12-week Hatha yoga program on redox status in individuals with PD.
Hypothesis 1a: Participants in the intervention group will have greater increases in total GSH levels and GSH: GSSG ratios from baseline than participants in the wait-list control group.
Hypothesis 1b: Compared to pre-intervention, wait-list participants will have higher total GSH levels and GSH: GSSG ratios after receiving the intervention.
Aim 2: Examine the effect of a 12-week Hatha yoga program on motor function (gait, balance, strength, flexibility, and physical activity level) and psychosocial well-being (mood, cognitive function, sleep quality, QoL) in individuals with PD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals diagnosed with idiopathic PD;
- •On optimized dopaminergic therapy for 4 weeks prior to enrollment; and
- •Have not practiced any form of yoga regularly (more than 2 days a week) in the past 6 months; and
- •Not currently participating in a supervised exercise program more than 2 days a week
排除标准
- •Atypical Parkinsonism or other significant brain conditions such as a stroke;
- •Fell more than once in the past 3 months;
- •Moderate to severe cognitive impairment (scored <26) as indicated by the Montreal Cognitive Assessment;
- •Decline in immune function such as pneumonia or systemic infection;
- •Spinal fusion or other orthopedic surgery in the past 6 months;
- •Unstable cardiovascular conditions;
- •Significant mental disease or psychosis;
- •Not able to ambulate 6 meters steadily without assistive device.
研究组 & 干预措施
Immediate treatment
Participants who are randomly assigned to the immediate treatment group will receive 60-minute biweekly Hatha yoga for 12 weeks.
干预措施: Hatha yoga (Other)
Waitlist control
Participants who are randomly assigned to the wait-list group will receive no intervention during the first 12 weeks. Not only will they serve as the comparative group, they will also serve as their own control and receive the same yoga intervention at the end of 12 weeks when the immediate treatment group completed their program.
干预措施: Hatha yoga (Other)
结局指标
主要结局
Redox status
时间窗: 12 weeks
The antioxidant glutathione (GSH) and the GSH: glutathione disulfide (GSSG) ratio will be measured at baseline and at the end of the program.
次要结局
- Sleep quality(12 weeks)
- Cognitive function(12 weeks)
- Quality of Life(12 weeks)
- Mood(12 weeks)
- Physical activity level(12 weeks)
- Motor function(12 weeks)