Effect of Lozenges Containing Probiotic Lactobacilli on Enamel Demineralization Assed by QLF

Not Applicable

Completed

• Conditions: Caries Dentalis
• Interventions: Biological: Placebo; Biological: L. retueri

• Registration Number: NCT01738958
• Lead Sponsor: University of Copenhagen

Brief Summary

Clinical trials in children and adults have suggested that daily consumption of probiotic lactic acid bacteria can reduce caries risk and caries development in primary teeth in preschool and stop root caries in the elderly. However, it is not known whether probiotic bacteria can affect the increased porosity in young permanent teeth in children and adolescents with many cavities.

It can be difficult to measure the increased porosity of the enamel by tooth decay, but this can be done using quantitative laser fluorescence (QLF). The method is based on visible light with a wavelength of 370 nm, addressing enamel. This produces an image consisting of red and green color tones and the dominant color of the enamel is green. Increased porosity of the enamel, resulting in a reduction of the auto-fluorescence and the loss (or gain) of the mineral can be quantified by means of a corresponding software.

The purpose of this study is to investigate the effect of a daily supplement of probiotic lactic acid bacteria on the loss of mineral in enamel assessed with QLF. The null hypothesis is that the mineral content will not differ from baseline in either the test group or the placebo group.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-09
• Study First Submitted: 2012-11-28
• Study First Submitted QC: 2012-11-29
• Study First Posted: 2012-11-30
• Primary Completion: 2013-07
• Study Completion: 2014-03
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-02
• Last Update Posted: 2014-12-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

• two sites with white spot lesions in anterior teeth

Exclusion Criteria

• antibiotic treatment within 2 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	Placebo tablets, two times a day for 6 weeks
Probiotic lactobacilli	L. retueri	L. reuteri, two times a day for 6 weeks

Primary Outcome Measures

Name	Time	Method
Change in enamel porosity	Baseine and 12 weeks	Change in enamel porosity assed by QLF

Trial Locations

Locations (1)

Ishøj kommunale tandpleje; 🇩🇰 Ishøj, Denmark