Effect of verb treatment on sentence production in aggrammatism

Not Applicable

• Conditions: aphasia.; Aphasia; R47.01

• Registration Number: IRCT20191112045415N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 17 December 2019

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

Patient symptoms of non-fluent aphasia and aphasia quotient (AQ) between 51 to 75 on the test P-DAB-1 that represents the moderate aphasia
Earn more than 50% on the subscales of Auditory Comprehension and Continuous Instructions on the P-DAB-1 test
Agrammatic sentence production according to descriptive speech (Bird's Nest) and story retelling (three kids) in a way that speech is distorted and non-fluent; the percentage of sentences is reduced, and production of grammatical morphemes and verbs is reduced
Difficulty in the verb tense inflection with less than 50 % in accuracy of regular and irregular verb tense inflection
The ability to read in the subtest of single word reading in Bilingual Aphasia Test (BAT)
Right-handed patient (using Edinburgh scale)
Patients who are Persian monolingual or are fluent in Persian if they are bilingual
Normal or near normal visual ability
Normal or near normal hearing
Minimum 9th grade education
The patient has a stroke lesion on the left side of the brain, which last at least six months of its occurrence
Aged between 18 - 65 years old

Exclusion Criteria

History of neurological and psychological problems, speech and language problems, and learning problems
Patients with apraxia
Patients with Dysarthria in informal assessment
Sign of claustrophobia
Pregnant female subjects
Subjects who have metal prosthesis

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Trained and generalization verb tense inflection score. Timepoint: verb tense inflection assessment for 17 times: 3 baselines, 12 during treatment (once per week for 12 weeks), 14 and 30 days after treatment. Method of measurement: verb tense inflection assessment test.;Trained and generalization sentence production score. Timepoint: sentence production assessment for 17 times: 3 baselines, 12 during treatment (once per week for 12 weeks), 14 and 30 days after treatment. Method of measurement: sentence production test.;The place of the activated brain area. Timepoint: brain activation imaging 2 times: once pre-treatment and once after treatment. Method of measurement: functional magnetic resonance imaging.

Secondary Outcome Measures

Name	Time	Method
Sentence production score. Timepoint: sentence production assessment for 17 times: 3 baselines, 12 during treatment (once per week for 12 weeks), 14 and 30 days after treatment. Method of measurement: sentence production assessment test.