Effect of Yoga on respiratory disease

Recruiting

Conditions: Mild and Moderate COPD

Registration Number: CTRI/2018/03/012731

Lead Sponsor: Vallabhbhai Patel Chest Institute

Brief Summary: Thepresent study is a randomized, open label, parallel design, controlled clinicalstudy to evaluate the effects of yogic intervention on pulmonary functions,clinical symptoms, oxidative stress markers, inflammation & immunitymarkers and health status parameters, in patients of COPD. COPD is a chronicinflammatory disorder with associated immunological changes, hence markers ofinflammation, immunity and oxidative stress will be assessed in both controlsas well as yoga exposed groups (both groups will be given Fixed dose inhaler andSOS L-Salbutamol treatment for COPD). Research methodology is as per ICH-GCPguidelines and protocol has been approved by the Institutional Ethical Committee.In the area of monitoring COPD, FeNO correlates with symptom frequency andbronchodilator use, therefore, in the present study FeNO will be used topredict the response of COPD patients to yogic intervention. The BODE index, isa multidimensional scoring system and capacity index used to test patients whohave been diagnosed with COPD and to predict long-term outcomes for them. Theindex uses four factors (Body-mass, Obstruction, Dyspnea, and Exercise) topredict risk of death from the disease. Isoprostanes are prostaglandin analogsproduced by free radical-catalyzed peroxidation of arachidonic acid.8-isoprostane is useful in the measurement of oxidative stress in lungs,systemic oxidative stress. In addition tothese, markers of inflammation and immunity viz. osteoprotogerin, CC-16, TNF-Î±,will be measured in patients of COPD. This will be correlated with the bloodcells counts i.e. neutrophil-lymphocyte ratio, which play an important role inthe early and late phase of COPD. Finally, the effects of yogic intervention onquality of life parameters will be assessed by using St. Georgeâ€™s RespiratoryQuestionnaire for COPD patients (SGRQ-C).

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 70

Inclusion Criteria

Patients of 40-65 age groups, irrespective of gender Patients with clinical diagnosis of COPD Patient who has given written informed consent to participate in the study Patient relatively stable, ambulatory and cooperative Smokers (anyone who had smoked during the last one year will be considered a smoker) and non- smokers.

Exclusion Criteria

Patient below 40 years and above 65 years Unwilling patients Patients had any respiratory tract infection during the past 4 week Patients with any other systemic disorder viz.
diabetes mellitus, rheumatic heart disease, renal disease, hepatic dysfunction, any CNS disorder etc.
Pregnant / lactating females Patients hypersensitive to any of the conventional COPD drugs Patients who cannot attend Yoga course for any reason.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improved Pulmonary functions	3 months

Secondary Outcome Measures

Name	Time	Method
Improved Quality of Life	Markers of oxidative stress and inflammation

Trial Locations

Locations (1): Out Patient Department (OPD) of Pulmonary Medicine, Viswanathan Chest Hospital
🇮🇳
North, DELHI, India
Out Patient Department (OPD) of Pulmonary Medicine, Viswanathan Chest Hospital
🇮🇳North, DELHI, India
Prof Kavita Gulati
Principal investigator
9818033085
kavgul2002@yahoo.com