Effects of hyperbaric oxygen on renal pressor response in chronic kidney disease patients with and without intact renal innervation.
Completed
- Conditions
- chronic kidney disease10029149
- Registration Number
- NL-OMON42307
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
age 18 years or over
able to give informed consent;For CKD patients:
eGFR <45 ml/min
Exclusion Criteria
- not willing to be informed about unexpected findings during the study
- (possible) pregnancy
- known or suspected diseases or conditions *other than CKD related* that could interfere with the study;- diagnosed hypertension pre-existing to CKD;Contraindications to hyperbaric oxygen:
- Severe lung disease
- Epilepsy
- Unable to equalise
- Heart failure
- Internal Cardiac Defibrilator
- Claustrophobia
- Any other reason for being not fit for HBO, as determined by the hyperbaric physician
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Relative change in systemic vascular resistance.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Changes in blood pressure, heart rate, relative changes in cardiac output and<br /><br>spontaneous baroreflex sensitivity (BRS).</p><br>