Enhancing Cognitive Control in Mild Cognitive Impairment Via Non-invasive Brain Stimulation
- Conditions
- Mild Cognitive Impairment
- Interventions
- Device: Transcranial alternating current stimulation
- Registration Number
- NCT04647032
- Lead Sponsor
- University of California, San Francisco
- Brief Summary
The overall goal of this project is to improve cognitive control abilities in adults with mild cognitive impairment (MCI) through a form of non-invasive brain stimulation, transcranial alternating current stimulation (tACS).
- Detailed Description
30 older adults aged 60-80 years with md-aMCI were randomized to 8 sessions of transcranial alternating current stimulation (tACS) with simultaneous cognitive control training (CCT). The intervention took place within the participant's home without direct researcher assistance. Half of the participants received prefrontal theta tACS during CCT and the other half received control tACS. Outcomes were assessed pre and post intervention.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- English speaking
- Grade 12 or more education
- Normal or corrected to normal vision and hearing
- Ability to complete cognitive tasks
- Ability to cooperate and comply with all study procedures
- Ability to tolerate tACS
- Montreal Cognitive Assessment score: 17-28
- -1 z-score on immediate memory, delayed memory, fluency, processing speed, or task switch
- Self-reported memory complaint
- Neurological or psychiatric disorders other than mild cognitive impairment
- Receiving investigational medications or have participated in a trial with investigational medications within last 30 days
- Family history of epilepsy
- Implanted electronic devices (e.g., pacemaker)
- Prior head trauma
- Pregnant
- IQ < 80
- Taking cholinesterase inhibitory, memantine, or psychotropic medication
- Taking anti-depressants or anti-anxiety medication
- Color blind
- Substance abuse
- Glaucoma
- Macular degeneration
- Amblyopia (lazy eye)
- Strabismus (crossed eyes)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Delta Stimulation Group Transcranial alternating current stimulation This group will receive 1 Hz (delta) stimulation Theta Stimulation Group Transcranial alternating current stimulation This group will receive 6 Hz (theta) stimulation
- Primary Outcome Measures
Name Time Method Divided Attention Performance Post-tACS (1-month follow-up), approximately 1 month after baseline Divided attention was assessed as the difficulty level achieved during perceptual discrimination performance while participants were engaged in the Akili AKL-T01 task. Higher is better.
Sustained Attention Performance Post-tACS (1-month follow-up), approximately 1 month after baseline Sustained attention was assessed via response times to visual targets during the continuous performance task. Lower is better.
Working Memory Performance Post-tACS (1-month follow-up), approximately 1 month after baseline Working memory was assessed as the average maximum number correct from the ACE-X span tasks - memory for order of illuminated squares
- Secondary Outcome Measures
Name Time Method Instrumental Activities of Daily Living (IADL) Post-tACS (1-month follow-up), approximately 1 month after baseline Scores on the IADL will be assessed pre and post intervention. Higher scores are better (minimum = 0, maximum = 4).
Trial Locations
- Locations (1)
University of California, San Francisco
🇺🇸San Francisco, California, United States