PET Study of Acetylcholine Esterase Activity in Alzheimer's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 主要终点
- PET with 11C MP4 as a tracer to identify acetylcholine esterase values in patients with neurodegenerative diseases.
研究概览
简要总结
The aim of this study is to understand regional variations in acetylcholine esterase activity in Alzheimer's disease. In this study the aim is to identify by PET the physiological values of the regional activity of acetylcholine esterase using the 11C PM4 tracer and to study by PET and 11C PM4 the brain activity of acetylcholine esterase in a group of patients with Alzheimer's disease, enrolled according to the inclusion and exclusion criteria. The PET data will be correlated with the clinical, neuropsychological and morphological data acquired by MRI and with the clinical-cognitive outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients diagnosed with Alzheimer's disease;
- •patients must have undergone an instrumental morphological examination to exclude other neurological pathologies.
排除标准
- •positive history of major head trauma;
- •clinically active somatic diseases.
结局指标
主要结局
PET with 11C MP4 as a tracer to identify acetylcholine esterase values in patients with neurodegenerative diseases.
时间窗: 4 years
Development of a new PET method for the in vivo measurement of acetylcholine esterase activity at the cortical level to be used as an indicator of the presence of disease.
次要结局
未报告次要终点
研究者
Chiti Arturo
Professor in Diagnostic Imaging and Radiotherapy Faculty of Medicine and Surgery, Vita-Salute San Raffaele University Director, Department of Nuclear Medicine, IRCCS Ospedale San Raffaele
IRCCS San Raffaele