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Clinical Trials/NCT04016857
NCT04016857
Completed
Not Applicable

Effects of Remote Ischemic Preconditioning on Renal Outcomes Following Lower Limb Revascularization

University of Messina1 site in 1 country50 target enrollmentJanuary 15, 2018
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ConditionsIschemic PreconditioningAcute Kidney InjuryLimb Ischemia

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Ischemic Preconditioning
Sponsor
University of Messina
Enrollment
50
Locations
1
Primary Endpoint
AKI
Status
Completed
Last Updated
4 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The aim of this study is to evaluate the role of remote ischemic preconditioning (RIPC) in preventing acute kidney injury after lower limb revascularization.

Remote ischemic preconditioning(RIPC) is a simple, cost-free and non invasive procedure (transient upper limb ischemia/reperfusion) that could provide organ protection (Heart, Brain and Kidney) following ischemia injuries.

Registry
clinicaltrials.gov
Start Date
January 15, 2018
End Date
June 15, 2019
Last Updated
4 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Alberto Noto

Professor of Anaesthesia

University of Messina

Eligibility Criteria

Inclusion Criteria

  • •Patients scheduled for open limb revascularization

Exclusion Criteria

  • •Peripheral vascular disease affecting upper limbs
  • •Chronic kidney disease in stage 4 or 5 (eGFR\<30 ml/min/1,73m2)
  • •Patients underwent contrast-enhanced radiological exams in the previous 7 days
  • •Treatment with glibencamide or prostaglandins

Outcomes

Primary Outcomes

AKI

Time Frame: 72 Hours

the incidence of Acute Kidney Injury, defined as decrease of 35% in GFR compared to preoperative.

Secondary Outcomes

  • AKI Risk Score(24 Hours)

Study Sites (1)

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